Misfolded proteins in Alzheimer's disease and type II diabetes.
Misfolded proteins in Alzheimer's disease and type II diabetes.
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DOI：
10.1039/c1cs15112f
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发表时间：
2012-01-21
影响因子：
46.2
通讯作者：
Lim MH
中科院分区：
文献类型：
--
作者：
DeToma AS;Salamekh S;Ramamoorthy A;Lim MH
这篇综述介绍了两种淀粉样蛋白蛋白，淀粉样蛋白（Aβ）胡椒和胰岛淀粉样多肽（IAPP）的描述，它们的错误折叠特性在阿尔茨海默氏病（AD）（AD）（AD）中实施，分别与II型糖尿病相似，并与某些蛋白质疾病相似。相关条件。并强调研究与人类疾病相关的一些主要考虑因素，它们的物理形成，聚集，与金属离子和其他蛋白质伴侣的相互作用以及靶向的小分子，并呈现了金属-Aβ相互作用和神经毒性的小分子。
This review presents descriptions of two amyloidogenic proteins, amyloid-β (Aβ) peptides and islet amyloid polypeptide (IAPP), whose misfolding propensities are implicated in Alzheimer’s disease (AD) and type II diabetes, respectively. Protein misfolding diseases share similarities, as well as some unique protein-specific traits, that could contribute to the initiation and/or development of their associated conditions. Aβ and IAPP are representative amyloidoses and used to highlight some of the primary considerations for studying misfolded proteins associated with human diseases. Among these factors, their physiological formation, aggregation, interactions with metal ions and other protein partners, and toxicity are presented. Small molecules that target and modulate the metal-Aβ interaction and neurotoxicity are included to illustrate one of the current approaches for studying the complex nature of misfolded proteins at the molecular level.
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影响因子：
64.5
作者：
Duce JA;Tsatsanis A;Cater MA;James SA;Robb E;Wikhe K;Leong SL;Perez K;Johanssen T;Greenough MA;Cho HH;Galatis D;Moir RD;Masters CL;McLean C;Tanzi RE;Cappai R;Barnham KJ;Ciccotosto GD;Rogers JT;Bush AI
通讯作者：
Bush AI
影响因子：
--
作者：
Braymer JJ;Detoma AS;Choi JS;Ko KS;Lim MH
通讯作者：
Lim MH
影响因子：
4.6
作者：
Chen, Tingting;Wang, Xiaoyong;Guo, Zijian
通讯作者：
Guo, Zijian
影响因子：
5.8
作者：
Bandyopadhyay S;Huang X;Lahiri DK;Rogers JT
通讯作者：
Rogers JT
影响因子：
3.4
作者：
Choi, Jung-Suk;Braymer, Joseph J.;Lim, Mi Hee
通讯作者：
Lim, Mi Hee