Assessing the Ecological Risks of Per- and Polyfluoroalkyl Substances: Current State-of-the Science and a Proposed Path Forward.
Assessing the Ecological Risks of Per- and Polyfluoroalkyl Substances: Current State-of-the Science and a Proposed Path Forward.
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评估全氟烷基和多氟烷基物质的生态风险：当前科学状况和拟议的前进道路。
DOI：
10.1002/etc.4869
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发表时间：
2021-03
影响因子：
4.1
通讯作者：
Valsecchi S
中科院分区：
文献类型：
--
作者：
Ankley GT;Cureton P;Hoke RA;Houde M;Kumar A;Kurias J;Lanno R;McCarthy C;Newsted J;Salice CJ;Sample BE;Sepúlveda MS;Steevens J;Valsecchi S
Per‐ and poly‐fluoroalkyl substances (PFAS) encompass a large, heterogenous group of chemicals of potential concern to human health and the environment. Based on information for a few relatively well‐understood PFAS such as perfluorooctane sulfonate and perfluorooctanoate, there is ample basis to suspect that at least a subset can be considered persistent, bioaccumulative, and/or toxic. However, data suitable for determining risks in either prospective or retrospective assessments are lacking for the majority of PFAS. In August 2019, the Society of Environmental Toxicology and Chemistry sponsored a workshop that focused on the state‐of‐the‐science supporting risk assessment of PFAS. The present review summarizes discussions concerning the ecotoxicology and ecological risks of PFAS. First, we summarize currently available information relevant to problem formulation/prioritization, exposure, and hazard/effects of PFAS in the context of regulatory and ecological risk assessment activities from around the world. We then describe critical gaps and uncertainties relative to ecological risk assessments for PFAS and propose approaches to address these needs. Recommendations include the development of more comprehensive monitoring programs to support exposure assessment, an emphasis on research to support the formulation of predictive models for bioaccumulation, and the development of in silico, in vitro, and in vivo methods to efficiently assess biological effects for potentially sensitive species/endpoints. Addressing needs associated with assessing the ecological risk of PFAS will require cross‐disciplinary approaches that employ both conventional and new methods in an integrated, resource‐effective manner. Environ Toxicol Chem 2021;40:564–605. © 2020 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. This article has been contributed to by US Government employees and their work is in the public domain in the USA.
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DOI：
10.1016/j.scitotenv.2017.11.141
发表时间：
2018-04-01
期刊：
The Science of the total environment
影响因子：
--
作者：
Bangma JT;Reiner JL;Lowers RH;Cantu TM;Scott J;Korte JE;Scheidt DM;McDonough C;Tucker J;Back B;Adams DH;Bowden JA
通讯作者：
Bowden JA
DOI：
10.1007/978-3-642-18384-3_1
发表时间：
2011-01-01
期刊：
EFFECT-DIRECTED ANALYSIS OF COMPLEX ENVIRONMENTAL CONTAMINATION
影响因子：
--
作者：
Ankley, Gerald T.;Hockett, James R.;Mount, David R.
通讯作者：
Mount, David R.
影响因子：
4.1
作者：
Ankley, Gerald T.;LaLone, Carlie A.;Hornung, Michael W.
通讯作者：
Hornung, Michael W.
影响因子：
3.6
作者：
Bakke, Torgeir;Kallqvist, Torsten;Hylland, Ketil
通讯作者：
Hylland, Ketil
影响因子：
11.4
作者：
Armitage, James M.;Arnot, Jon A.;Wania, Frank
通讯作者：
Wania, Frank