Altered modular organization of functional connectivity networks in cirrhotic patients without overt hepatic encephalopathy.
Altered modular organization of functional connectivity networks in cirrhotic patients without overt hepatic encephalopathy.
复制标题
无明显肝性脑病的肝硬化患者功能连接网络的模块化组织改变
DOI：
10.1155/2014/727452
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发表时间：
2014
影响因子：
--
通讯作者：
Lu GM
中科院分区：
文献类型：
--
作者：
Zheng G;Zhang L;Zhang LJ;Li Q;Pan Z;Liang X;Shi D;Lu GM
轻微肝性脑病（MHE）与功能连接的变化有关。为了研究MHE进展中功能连接的模块化变化模式，对24例MHE患者、31例无轻微肝性脑病（非HE）的肝硬化患者和38例健康对照者进行静息态功能磁共振成像。将纽曼的指标（模块化Q值）最大化并在三组中进行比较。拓扑结构的作用与MHE的进展，说明了内部和模块间的连接变化。结果表明，MHE患者的Q值显著低于正常对照组（P < 0.01），而非HE患者的Q值显著低于非HE患者（P > 0.05），且Q值与神经心理测验评分相关，而与血氨水平和Child-Pugh评分无关。随着MHE的进展，皮质下连接减少，皮质下模块分离增多。非HE患者与对照组有相同数量的连接节点，与MHE患者和健康对照组相比，有更多的枢纽。我们的研究结果支持，无论是内部和模块间的连接，特别是那些相关的皮质下区域，在阿尔茨海默病患者持续受损。非HE患者的集线器和连接器节点的调整可能是对其功能连接网络中模块性降低的补偿。
Minimal hepatic encephalopathy (MHE) is associated with changes in functional connectivity. To investigate the patterns of modular changes of the functional connectivity in the progression of MHE, resting-state functional magnetic resonance imaging was acquired in 24 MHE patients, 31 cirrhotic patients without minimal hepatic encephalopathy (non-HE), and 38 healthy controls. Newman's metric, the modularity Q value, was maximized and compared in three groups. Topological roles with the progression of MHE were illustrated by intra- and intermodular connectivity changes. Results showed that the Q value of MHE patients was significantly lower than that of controls (P < 0.01) rather than that of non-HE patients (P > 0.05), which was correlated with neuropsychological test scores rather than the ammonia level and Child-Pugh score. Less intrasubcortical connections and more isolated subcortical modules were found with the progression of MHE. The non-HE patients had the same numbers of connect nodes as controls and had more hubs compared with MHE patients and healthy controls. Our findings supported that both intra- and intermodular connectivity, especially those related to subcortical regions, were continuously impaired in cirrhotic patients. The adjustments of hubs and connector nodes in non-HE patients could be a compensation for the decreased modularity in their functional connectivity networks.
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影响因子：
5.7
作者：
Alexander-Bloch, Aaron;Lambiotte, Renaud;Roberts, Ben;Giedd, Jay;Gogtay, Nitin;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
影响因子：
2.9
作者：
Liao, Ling-min;Zhou, Li-xue;Ma, Shu-hua
通讯作者：
Ma, Shu-hua
影响因子：
25.7
作者：
Butterworth, RE
通讯作者：
Butterworth, RE
影响因子：
4.3
作者：
Meunier D;Lambiotte R;Bullmore ET
通讯作者：
Bullmore ET