Intrinsic functional connectivity during continuous maintenance and suppression of emotion in bipolar disorder.
Intrinsic functional connectivity during continuous maintenance and suppression of emotion in bipolar disorder.
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DOI：
10.1007/s11682-019-00109-4
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发表时间：
2020-10
影响因子：
3.2
通讯作者：
Spielberg JM
中科院分区：
文献类型：
--
作者：
Anand A;Grandhi J;Karne H;Spielberg JM
静息状态连通性研究，检查无约束的低频BOLD波动，报道了双相情感障碍（BP）的不一致异常。在这项研究中，我们研究了持续情绪调节任务（CERT）约束下BP患者在抑郁（BPD）和躁狂（BPM）状态下的内在脑连接，以及健康对照组。包括无药物治疗的参与者，诊断为BP （BPD = 27, BPM = 30）或健康对照（N = 33）。我们使用CERT范式收集了2个fMRI扫描，其中参与者连续观看负面图片，并使用重新评估技术保持情绪（维持）或抑制情绪（抑制）。以网络为基础的统计和图论分析检验了(i)条件（组内）的主要影响和（ii）组和条件的相互作用。在健康参与者中，maintenance主要涉及枕叶和顶叶皮层（p< 0.001），而SUPPRESS也涉及额叶和扣带皮层（p= 0.023）。组（BPD vs. BPM）和病情之间的相互作用显示，在BPD的维持和BPM的抑制期间，涉及额叶下部的网络更强（p= 0.037）。关键节点的图论性质（即聚类系数）也通过条件相互作用证明了显著组。我们观察到正常和异常情绪调节中与BP相关的网络特性变化，这为BP情感障碍的神经基础提供了见解。
Resting-state connectivity studies, which examine unconstrained low frequency BOLD fluctuations, have reported inconsistent abnormalities in bipolar disorder (BP). In this study, we investigated intrinsic brain connectivity under the constraints of a Continuous Emotion Regulation Task (CERT) in BP patients in depressed (BPD) and manic (BPM) states, along with healthy control participants. Medication-free participants, with either a diagnosis of BP (BPD = 27, BPM = 30) or healthy controls (N = 33) were included. We collected 2 fMRI scans using the CERT paradigm, in which participants continuously watched negative pictures and either maintained emotions (MAINTAIN) or suppressed emotion using reappraisal techniques (SUPPRESS). Network-based statistic and graph theory analyses were examined for (i) the main effect of condition (within-group) and (ii) group and condition interactions. In healthy participants, MAINTAIN largely involved occipital and parietal cortices (p<.001), whereas SUPPRESS also recruited the frontal and cingulate cortices (p=.023). The interaction between group (BPD vs. BPM) and condition revealed a network involving the inferior frontal lobe which was stronger during MAINTAIN for BPD and during SUPPRESS for BPM (p=.037). Graph theory properties (i.e., clustering coefficient) for key nodes also evidenced significant group by condition interactions. We observed BP-related changes in network properties involved in normal and abnormal emotion regulation, which provide insights into the neural bases for affective disturbances in BP.
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影响因子：
11
作者：
Hibar, D. P.;Westlye, L. T.;van Erp, T. G. M.;Rasmussen, J.;Leonardo, C. D.;Faskowitz, J.;Haukvik, U. K.;Hartberg, C. B.;Doan, N. T.;Agartz, I.;Dale, A. M.;Gruber, O.;Kraemer, B.;Trost, S.;Liberg, B.;Abe, C.;Ekman, C. J.;Ingvar, M.;Landen, M.;Fears, S. C.;Freimer, N. B.;Bearden, C. E.;Sprooten, E.;Glahn, D. C.;Pearlson, G. D.;Emsell, L.;Kenney, J.;Scanlon, C.;McDonald, C.;Cannon, D. M.;Almeida, J.;Versace, A.;Caseras, X.;Lawrence, N. S.;Phillips, M. L.;Dima, D.;Delvecchio, G.;Frangou, S.;Satterthwaite, T. D.;Wolf, D.;Houenou, J.;Henry, C.;Malt, U. F.;Boen, E.;Elvsashagen, T.;Young, A. H.;Lloyd, A. J.;Goodwin, G. M.;Mackay, C. E.;Bourne, C.;Bilderbeck, A.;Abramovic, L.;Boks, M. P.;van Haren, N. E. M.;Ophoff, R. A.;Kahn, R. S.;Bauer, M.;Pfennig, A.;Alda, M.;Hajek, T.;Mwangi, B.;Soares, J. C.;Nickson, T.;Dimitrova, R.;Sussmann, J. E.;Hagenaars, S.;Whalley, H. C.;McIntosh, A. M.;Thompson, P. M.;Andreassen, O. A.
通讯作者：
Andreassen, O. A.
影响因子：
5.7
作者：
Beall, Erik B.;Lowe, Mark J.
通讯作者：
Lowe, Mark J.
影响因子：
3
作者：
Beall, Erik B.
通讯作者：
Beall, Erik B.
影响因子：
10.5
作者：
Ormel, Johan;Petukhova, Maria;Kessler, Ronald C.
通讯作者：
Kessler, Ronald C.
DOI：
10.1176/appi.neuropsych.19.3.274
发表时间：
2007-06-01
影响因子：
2.9
作者：
Anand, Amit;Li, Yu;Lowe, Mark J.
通讯作者：
Lowe, Mark J.