MicroRNAs and the genetic network in aging.
MicroRNAs and the genetic network in aging.
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DOI：
10.1016/j.jmb.2013.01.023
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发表时间：
2013-10-09
影响因子：
5.6
通讯作者：
Slack, Frank
中科院分区：
文献类型：
--
作者：
Inukai, Sachi;Slack, Frank
MicroRNAs （miRNAs）包括一类对许多生物过程的转录后调控很重要的小rna。它们的组合功能模式，其中单个miRNA可以靶向许多基因，多个miRNA共享靶标，使它们特别适合调节“网络”水平的过程和途径。特别是，mirna最近被认为与衰老有关，这是一个已知涉及多种途径的复杂过程。来自全基因组miRNA表达谱研究的发现强调了衰老过程中miRNA功能的三个主题：许多miRNA是差异表达的，许多这样的miRNA靶向已知的衰老相关途径，以及miRNA表达随时间变化的全球趋势。此外，一些mirna在衰老过程中可能协调多种途径。阐明参与衰老过程的基因和mirna的潜在网络结构不仅有助于我们了解衰老及其相关发病机制，还有助于我们了解mirna如何连接不同的途径。
MicroRNAs (miRNAs) comprise a class of small RNAs important for the post-transcriptional regulation of numerous biological processes. Their combinatorial mode of function, in which an individual miRNA can target many genes and multiple miRNAs share targets, makes them especially suited for regulating processes and pathways at the “network” level. In particular, miRNAs have recently been implicated in aging which is a complex process known to involve multiple pathways. Findings from genome-wide miRNA expression profiling studies highlight three themes in miRNA function during aging: many miRNAs are differentially expressed, many such miRNAs target known aging-associated pathways, and there are global trends in miRNA expression change over time. In addition, several miRNAs have emerged as potentially coordinating multiple pathways during aging. Elucidating the underlying network structure of genes and miRNAs involved in aging processes promises to advance our understanding of not only aging and associated pathogenesis but also of how miRNAs can connect disparate pathways.
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