Bone marrow changes in adolescent girls with anorexia nervosa.
Bone marrow changes in adolescent girls with anorexia nervosa.
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DOI：
10.1359/jbmr.090805
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Gordon CM
中科院分区：
文献类型：
--
作者：
Ecklund K;Vajapeyam S;Feldman HA;Buzney CD;Mulkern RV;Kleinman PK;Rosen CJ;Gordon CM
早期骨质疏松症在患有神经性厌食症（AN）的青春期女孩中很常见，可能是由于红骨髓（RM）过早转化为黄骨髓所致。我们在1.0 T肢体扫描仪上对20名患者和20名健康对照者进行了右膝磁共振成像（MRI），年龄为16.2 ± 1.6岁（平均值± SD）。冠状位T1加权（T1 W）图像和T1图由T1弛豫图像生成。设盲的放射科医生使用0（均匀高信号，无RM）至4（全暗，完全RM）的信号强度量表，目视评估T1 W图像中股骨远端和胫骨近端干骺端的RM。AN受试者的股骨（0.64 vs 1.22，p = 0.03）和胫骨（0.54 vs 0.96，p = 0.08）干骺端RM评分几乎低2倍。在四个选定的区域（股骨和胫骨以及骨骺和干骺端）的松弛测量中，AN受试者的平均骨骺T1较高，但干骺端T1较低。骨骺和干骺端之间的净AN对照差异在股骨中为70 ms（+31 vs-35 ms，p = .02），在胫骨中的幅度较小。在松弛法数据从股骨的全宽相邻的生长板，AN受试者显示平均T1始终低于对照组的30至50毫秒，几乎在每个部分的采样区域。这些研究结果表明，青少年AN表现出过早的造血细胞转化为脂肪细胞在骨髓的外周骨骼可能是由于脂肪细胞成骨细胞分化的间充质干细胞池。© 2010美国骨与矿物质研究学会
Early osteoporosis is common among adolescent girls with anorexia nervosa (AN) and may result from premature conversion of red (RM) to yellow bone marrow. We performed right knee magnetic resonance imaging (MRI) on a 1.0 T extremity scanner in 20 patients and 20 healthy controls, aged 16.2 ± 1.6 years (mean ± SD). Coronal T1-weighted (T1W) images and T1 maps were generated from T1 relaxometry images. Blinded radiologists visually assessed RM in the distal femoral and proximal tibial metaphyses in T1W images using a scale of signal intensity from 0 (homogeneous hyperintensity, no RM) to 4 (all dark, complete RM). Subjects with AN exhibited nearly twofold lower metaphyseal RM scores in both the femur (0.64 versus 1.22, p = .03) and tibia (0.54 versus 0.96, p = .08). In relaxometric measurements of four selected regions (femur and tibia amd epiphysis and metaphysis), subjects with AN showed higher mean epiphyseal but lower metaphyseal T1. The net AN-control difference between epiphysis and metaphysis was 70 ms in the femur (+31 versus −35 ms, p = .02) and of smaller magnitude in the tibia. In relaxometry data from the full width of the femur adjacent to the growth plate, AN subjects showed mean T1 consistently lower than in controls by 30 to 50 ms in virtually every part of the sampling region. These findings suggest that adolescents with AN exhibit premature conversion of hematopoietic to fat cells in the marrow of the peripheral skeleton potentially owing to adipocyte over osteoblast differentiation in the mesenchymal stem cell pool. © 2010 American Society for Bone and Mineral Research
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影响因子：
2.1
作者：
Golden, Neville H.
通讯作者：
Golden, Neville H.
影响因子：
6.2
作者：
Ackert-Bicknell, Cheryl L.;Demissie, Serkalem;Rosen, Clifford J.
通讯作者：
Rosen, Clifford J.
影响因子：
5.8
作者：
Bredella, Miriam A.;Fazeli, Pouneh K.;Klibanski, Anne
通讯作者：
Klibanski, Anne
影响因子：
--
作者：
Duque, G
通讯作者：
Duque, G
影响因子：
5.1
作者：
Gordon, CM;Goodman, E;LeBoff, MS
通讯作者：
LeBoff, MS