Immunohistochemical localization and dilatatory effect of substance P on human cerebral vessels
Immunohistochemical localization and dilatatory effect of substance P on human cerebral vessels
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P物质对人脑血管的免疫组织化学定位及扩张作用
DOI：
10.1016/0006-8993(82)90290-6
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发表时间：
1982
期刊：
影响因子：
2.9
通讯作者：
R. Uddman
中科院分区：
文献类型：
--
作者：
L. Edvinsson;R. Uddman
已知人脑血管接受丰富的肾上腺素能和胆碱能神经纤维供应，这通过使用甲醛荧光和乙酰胆碱酯酶组织化学6来证明。在过去的十年中，免疫组织化学方法的快速发展使得对神经元储存肽的研究成为可能13。因此，在脑血管周围的神经中发现的第一种神经肽是血管活性肠多肽（VIP）a，15。已观察到VIP对脑循环的有效作用; VIP能够在体外和原位松弛软脑膜动脉15，~ 6，22，增加脑血流量11，t6，23，并提高脑氧代谢率6。最近的免疫组织化学研究表明，另一种神经肽P物质（SP），存在于发育良好的精细，实验室动物软脑膜动脉中的静脉曲张神经纤维2，4，2L研究进一步表明，SP可以在体外和原位扩张猫软脑膜动脉4。本研究的目的是评估是否含有SP的神经纤维也发生在人脑血管和研究SP对人软脑膜动脉的药理作用。
Human brain vessels are known to receive a rich supply of adrenergic and cholinergic nerve fibers, demonstrated by the use of formaldehyde fluorescence and acetyl cholinesterase histochemistry 6. The rapid development of immunohistochemical methods during the last decade has allowed for studies on neuronally stored peptides 13. Thus, the first neuropeptide to be found in nerves around cerebral vessels was vasoactive intestinal polypeptide (VIP) a, 15. Potent effects of VIP have been observed on the cerebral circulation; VIP is able to relax pial arteries in vitro and in situ 15,~ 6, 22, to increase the cerebral blood flowll, t6, 23 and to enhance the cerebral metabolic rate of oxygen 6.Recent immunohistochemical studies have shown that yet another neuronal peptide substance P (SP), occurs in a well-developed network of delicate, varicosed nerve fibers in pial arteries from laboratory animals2, 4, 2L The studies have furthermore shown that SP may dilate feline pial arteries both in vitro and in situ 4. The present study was undertaken to evaluate whether SP-containing nerve fibers occurs also in human brain vessels and to investigate the pharmacological effects of SP on human pial arteries.
DOI：
10.1152/ajpheart.1980.239.6.h765
发表时间：
1980
期刊：
The American journal of physiology
影响因子：
--
作者：
Wei,EP;Kontos,HA;Said,SI
通讯作者：
Said,SI