Interaction of microglia with infiltrating immune cells in the different phases of stroke.
Interaction of microglia with infiltrating immune cells in the different phases of stroke.
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DOI：
10.1111/bpa.12911
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Meisel A
中科院分区：
文献类型：
--
作者：
Berchtold D;Priller J;Meisel C;Meisel A
中风及其并发症是全球死亡率和发病率的主要原因之一。脑缺血触发脑中的炎症反应，其由常驻小胶质细胞的激活以及外周髓样和淋巴样细胞向脑实质中的浸润控制。这种炎症已被证明对中风结果既有有益的影响，也有有害的影响。本文重点综述了髓系细胞的功能及其与脑卒中不同阶段浸润淋巴细胞的相互作用。详细了解不同免疫细胞亚群在脑缺血过程中的作用和时间特异性，对于特异性促进炎症对卒中结局的有益影响和抑制其有害影响至关重要。中风是全球死亡率和发病率的主要原因之一。由骨髓和淋巴免疫细胞介导的脑炎症是中风病理学的固有组成部分，并有助于缺血后的功能结果。
Stroke, in association with its complications, is one of the leading causes of mortality and morbidity worldwide. Cerebral ischemia triggers an inflammatory response in the brain that is controlled by the activation of resident microglia as well as the infiltration of peripheral myeloid and lymphoid cells into the brain parenchyma. This inflammation has been shown to have both beneficial and detrimental effects on stroke outcome. The focus of this review lies on the functions of myeloid cells and their interaction with infiltrating lymphocytes in different phases of stroke. A detailed and time‐specific understanding of the contribution of different immune cell subsets during the course of cerebral ischemia is crucial to specifically promote beneficial and inhibit detrimental effects of inflammation on stroke outcome. Stroke is one of the leading causes of mortality and morbidity worldwide. Brain inflammation, mediated by myeloid and lymphoid immune cells, is an inherent component of stroke pathology and contributes to the functional outcome after ischemia.
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影响因子：
9.3
作者：
Dambinova, SA;Khounteev, GA;Skoromets, AA
通讯作者：
Skoromets, AA
影响因子：
6.3
作者：
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Allan, Stuart M.
DOI：
10.1016/j.bbi.2016.08.009
发表时间：
2017-08
期刊：
Brain, behavior, and immunity
影响因子：
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作者：
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通讯作者：
Buckwalter MS
影响因子：
8.3
作者：
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通讯作者：
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影响因子：
20.3
作者：
Carlsen, HS;Baekkevold, ES;Brandtzaeg, P
通讯作者：
Brandtzaeg, P