Gender differences in risk factors for aberrant prescription opioid use.
Gender differences in risk factors for aberrant prescription opioid use.
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DOI：
10.1016/j.jpain.2009.07.016
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Wasan AD
中科院分区：
文献类型：
--
作者：
Jamison RN;Butler SF;Budman SH;Edwards RR;Wasan AD
这是一项纵向预测性研究，旨在检查慢性疼痛患者中阿片类药物滥用风险的临床相关性的性别差异。要求275名男性和335名女性患者接受阿片类药物治疗慢性非癌症疼痛，并完成一系列基线问卷，包括修订后的疼痛患者筛选和阿片类药物评估（SOAPP-R）。5个月后，对受试者进行结构化处方药使用访谈（处方药使用问卷; PDUQ），并提交尿样进行毒理学评估。他们的主治医生还完成了药物滥用行为检查表（处方阿片类药物治疗问卷; POTQ）。在5个月的随访中，女性在PDUQ上表现出更高的得分（p<0.05），而男性在POTQ上有更高的医生评定的异常药物行为发生率（p<0.05）。对SOAPP-R、PDUQ和POTQ的项目分析显示，女性在与心理困扰相关的项目上得分较高，而男性患者倾向于报告有更多的法律的和行为问题。这些结果表明，与处方阿片类药物滥用相关的风险因素可能在男性和女性之间存在差异。了解慢性疼痛患者药物滥用风险的性别差异对于临床评估和治疗非常重要。这项研究表明，由于情绪问题和情感困扰，女性滥用阿片类药物的风险更大，而男性由于法律的和有问题的行为问题，往往滥用阿片类药物。
This is a longitudinal predictive study to examine gender differences in the clinical correlates of risk for opioid misuse among chronic pain patients prescribed opioids for pain. Two hundred seventy five male and 335 female patients prescribed opioids for chronic noncancer pain were asked to complete a series of baseline questionnaires, including the revised Screener and Opioid Assessment for Pain Patients (SOAPP-R). After five months the subjects were administered a structured prescription drug use interview (Prescription Drug Use Questionnaire; PDUQ), and submitted a urine sample for toxicology assessment. Their treating physicians also completed a substance misuse behavior checklist (Prescription Opioid Therapy Questionnaire; POTQ). At 5-month follow-up, women showed higher scores on the PDUQ (p<0.05), while men had a higher incidence of physician-rated aberrant drug behavior on the POTQ (p<0.05). An item analysis of the SOAPP-R, PDUQ and POTQ showed that women tended to score higher on items relating to psychological distress, while the male patients tended to report having more legal and behavioral problems. These results suggest that risk factors associated with prescription opioid misuse may differ between men and women. Understanding gender differences in substance abuse risk among chronic pain patients is important for clinical assessment and treatment. This study suggests that women are at greater risk to misuse opioids due to emotional issues and affective distress, while men tend to misuse opioids due to legal and problematic behavioral issues.
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影响因子：
2.9
作者：
Michna, Edward;Jamison, Robert N.;Wasan, Ajay D.
通讯作者：
Wasan, Ajay D.
影响因子：
4.2
作者：
McCabe, SE;Teter, CJ;Boyd, CJ
通讯作者：
Boyd, CJ
影响因子：
7.4
作者：
Butler, SF;Budman, SH;Jamison, RN
通讯作者：
Jamison, RN
影响因子：
120.7
作者：
Joranson, DE;Ryan, KM;Dahl, JL
通讯作者：
Dahl, JL
影响因子：
--
作者：
Kessler, RC;Berglund, P;Walters, EE
通讯作者：
Walters, EE