Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast.
Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast.
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DOI：
10.1038/s41536-021-00133-3
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发表时间：
2021-03-29
影响因子：
7.2
通讯作者：
Zeugolis DI
中科院分区：
文献类型：
--
作者：
De Pieri A;Rochev Y;Zeugolis DI
基于细胞的无支架疗法寻求开发体外器官型三维（3D）组织样替代物，利用细胞的固有能力以人造设备无法比拟的效率和复杂性创造组织。尽管自动化系统已经实现，并且多年来在临床和商业领域已经见证了（一些）成功的故事，但体外器官发生远未成为标准的护理方式。这种有限的技术转让在很大程度上归因于可扩展性相关的成本，考虑到边界3D植入式装置的开发需要非常高数量的功能细胞和延长的离体培养期。在此，我们批判性地讨论了无支架细胞为基础的组织工程策略的进步和不足，沿着具有潜力的创新概念，以改变再生和修复医学。
Cell-based scaffold-free therapies seek to develop in vitro organotypic three-dimensional (3D) tissue-like surrogates, capitalising upon the inherent capacity of cells to create tissues with efficiency and sophistication that is still unparalleled by human-made devices. Although automation systems have been realised and (some) success stories have been witnessed over the years in clinical and commercial arenas, in vitro organogenesis is far from becoming a standard way of care. This limited technology transfer is largely attributed to scalability-associated costs, considering that the development of a borderline 3D implantable device requires very high number of functional cells and prolonged ex vivo culture periods. Herein, we critically discuss advancements and shortfalls of scaffold-free cell-based tissue engineering strategies, along with pioneering concepts that have the potential to transform regenerative and reparative medicine.
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影响因子：
6
作者：
Chase, Lucas G.;Yang, Sufang;Vemuri, Mohan C.
通讯作者：
Vemuri, Mohan C.
影响因子：
4.1
作者：
BATEMAN, JF;GOLUB, SB
通讯作者：
GOLUB, SB
影响因子：
1.2
作者：
Benny, Paula;Badowski, Cedric;Raghunath, Michael
通讯作者：
Raghunath, Michael
影响因子：
4.1
作者：
Ahmed, Meer N.;Shi, Delin;Syed-Picard, Fatima N.
通讯作者：
Syed-Picard, Fatima N.
影响因子：
7.2
作者：
Amer MH;Rose FRAJ;Shakesheff KM;Modo M;White LJ
通讯作者：
White LJ