Sex influences the association between haemostasis and the extent of lung lesions in tuberculosis.
Sex influences the association between haemostasis and the extent of lung lesions in tuberculosis.
复制标题
性别影响结核病止血与肺部病变程度之间的关联。
DOI：
10.1186/s13293-018-0203-9
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发表时间：
2018-10-10
影响因子：
7.9
通讯作者：
Feng Y
中科院分区：
文献类型：
--
作者：
Tan W;Soodeen-Lalloo AK;Chu Y;Xu W;Chen F;Zhang J;Sha W;Huang J;Yang G;Qin L;Wang J;Huang X;Shi J;Feng Y
背景世界范围内的结核病（TB）报告显示男性发病率偏高，然而，男性和女性之间的结核病的发病机制的差异，以及与这种差异的机制，很少调查。我们假设，肺损伤程度和临床指标的良好匹配的男性和女性新诊断的结核病，并统计分析这些指标之间的相关性和肺部病变的程度，可以提供深入了解结核病的性别偏见的机制。方法我们评估了痰标本的抗酸杆菌分级和编译的年龄匹配，新诊断的男性和女性结核病患者，无吸烟史或合并症。比较炎症生物标志物水平和常规血液学和凝血相关参数。二元Logistic回归分析被用来定义的指数和肺部病变之间的关联，和性别adjustment.ResultsWomen与TB的影响有一个更长的延迟比男性在寻求医疗保健后，发病的TB相关症状。与女性结核病患者相比，男性结核病患者有更严重的肺部病变（空洞和愈合相关特征）和更高的细菌计数。抗结核治疗前后的CT图像评分显示，女性比男性对治疗的反应更快。凝血和血小板相关指数是在多变量回归分析模型中与男性或女性TB组或组合。在单变量回归分析中，较低的淋巴细胞计数与空洞和更多的细菌计数相关，与性别、年龄和BMI无关。国际标准化比值（INR），凝血酶原时间（PT），平均血小板体积（MPV）和纤维蛋白原（FIB）水平与肺lesions.ConclusionsSex的影响，主要是受性别adjustment.ConclusionsSex影响止血和TB肺病变的程度之间的关联，这可能是一个机制，参与性别偏见的TB发病机制。
BackgroundWorldwide tuberculosis (TB) reports show a male bias in morbidity; however, the differences in pathogenesis between men and women with TB, as well as the mechanisms associated with such differences, are poorly investigated. We hypothesized that comparison of the degree of lung injury and clinical indices of well-matched men and women with newly diagnosed TB, and statistical analysis of the correlation between these indices and the extent of lung lesions, can provide insights into the mechanism of gender bias in TB.MethodsWe evaluated the acid-fast bacilli grading of sputum samples and compiled computed tomography (CT) data of the age-matched, newly diagnosed male and female TB patients without history of smoking or comorbidities. Inflammatory biomarker levels and routine haematological and coagulation-associated parameters were compared. Binary logistic regression analysis was used to define the association between the indices and lung lesions, and the influence of sex adjustment.ResultsWomen with TB have a longer delay in seeking healthcare than men after onset of the TB-associated symptoms. Men with TB have significantly more severe lung lesions (cavities and healing-associated features) and higher bacterial counts compared to women with TB. Scoring of the CT images before and after anti-TB treatment showed a faster response to therapy in women than in men. Coagulation- and platelet-associated indices were in models from multivariate regression analysis with groups of males or females with TB or in combination. In univariate regression analysis, lower lymphocyte counts were associated with both cavity and more bacterial counts, independent of sex, age and BMI. The association of international normalized ratios (INR), prothrombin times (PTs), mean platelet volumes (MPVs) and fibrinogen (FIB) level with lung lesions was mostly influenced by sex adjustment.ConclusionsSex influences the association between haemostasis and extent of TB lung lesions, which may be one mechanism involved in sex bias in TB pathogenesis.
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影响因子：
9.3
作者：
Murthy SE;Chatterjee F;Crook A;Dawson R;Mendel C;Murphy ME;Murray SR;Nunn AJ;Phillips PPJ;Singh KP;McHugh TD;Gillespie SH;REMoxTB Consortium
通讯作者：
REMoxTB Consortium
DOI：
10.1038/nri.2017.69
发表时间：
2017-11
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Cadena AM;Fortune SM;Flynn JL
通讯作者：
Flynn JL
DOI：
10.1164/rccm.201311-2106pp
发表时间：
2014-07-01
影响因子：
24.7
作者：
Ong, Catherine W. M.;Elkington, Paul T.;Friedland, Jon S.
通讯作者：
Friedland, Jon S.
影响因子：
56.9
作者：
GROSSMAN, CJ
通讯作者：
GROSSMAN, CJ
影响因子：
7
作者：
Achkar JM;Prados-Rosales R
通讯作者：
Prados-Rosales R