Yohimbine-induced amygdala activation in pathological gamblers: a pilot study.
Yohimbine-induced amygdala activation in pathological gamblers: a pilot study.
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DOI：
10.1371/journal.pone.0031118
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Borsook D
中科院分区：
文献类型：
--
作者：
Elman I;Becerra L;Tschibelu E;Yamamoto R;George E;Borsook D
有证据表明，药物成瘾与对压力的生理和心理反应增加有关。在这项初步的功能性磁共振成像（fMRI）研究中，我们评估了一种原型行为成瘾，即病理性赌博（PG），是否同样与对压力的反应增强有关。我们通过注射育亨宾（0.2-0.3 mg/kg，IV）诱导应激，育亨宾是一种α-2肾上腺素受体拮抗剂，在人类和实验室动物中引起应激样生理和心理效应，给4名PG受试者和5名非赌徒心理健康对照受试者。他们的fMRI大脑反应与主观压力和赌博冲动评级一起沿着评估。个体受试者的数据集的体素分析，利用广义线性模型的方法，显示显着的左杏仁核激活在所有PG受试者的育亨宾。这种杏仁核效应在五个对照组中没有观察到。育亨宾引起的主观压力等级在两组更大（虽然没有统计学显着）的平均反应在PG科目。另一方面，育亨宾并没有诱发赌博的冲动。目前的数据支持这一假设的大脑敏化药理学诱导的压力在PG。
There is evidence that drug addiction is associated with increased physiological and psychological responses to stress. In this pilot functional magnetic resonance imaging (fMRI) study we assessed whether a prototype behavioral addiction, pathological gambling (PG), is likewise associated with an enhanced response to stress. We induced stress by injecting yohimbine (0.2–0.3 mg/kg, IV), an alpha-2 adrenoceptor antagonist that elicits stress-like physiological and psychological effects in humans and in laboratory animals, to four subjects with PG and to five non-gamblers mentally healthy control subjects. Their fMRI brain responses were assessed along with subjective stress and gambling urges ratings. Voxelwise analyses of data sets from individual subjects, utilizing generalized linear model approach, revealed significant left amygdala activation in response to yohimbine across all PG subjects. This amygdala effect was not observed in the five control individuals. Yohimbine elicited subjective stress ratings in both groups with greater (albeit not statically significantly) average response in the PG subjects. On the other hand, yohimbine did not induce urges to gamble. The present data support the hypothesis of brain sensitization to pharmacologically-induced stress in PG.
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