Rapid Evolution of Sperm Produces Diverse Centriole Structures that Reveal the Most Rudimentary Structure Needed for Function.
Rapid Evolution of Sperm Produces Diverse Centriole Structures that Reveal the Most Rudimentary Structure Needed for Function.
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DOI：
10.3390/cells7070067
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发表时间：
2018-06-26
期刊：
影响因子：
6
通讯作者：
Avidor-Reiss T
中科院分区：
文献类型：
--
作者：
Avidor-Reiss T
中心粒是一种古老的亚细胞蛋白质细胞器，在许多真核生物中保持着保守的数量和结构。中心粒数量（每个细胞两个）受到严格的调控;当细胞准备分裂时，每个预先存在的中心粒只与一个中心粒成核。中心粒的结构是桶形的，具有九重对称的微管。微管的这种组织对于中心粒纤毛成核的祖先功能是必不可少的。在动物细胞中，中心粒有一个额外的作用：募集中心粒周围物质（PCM）形成中心体。因此，令人惊讶的是，在动物精子中，中心粒具有显着的结构多样性，其中一些是如此异常，以至于它们被称为非典型中心粒并且几乎无法识别。非典型中心粒保持形成中心体和成核新中心粒的能力，因此揭示了中心粒功能所需的最基本的结构。然而，非典型中心粒似乎不能形成纤毛。在这里，我们提出精子中心粒结构的多样性是由于精子头部和颈部形状的快速进化造成的。增强的多样性可能是由直接选择新的中心粒功能和多效性的组合驱动的，多效性消除了在精子功能中被破坏的中心粒特性。
Centrioles are ancient subcellular protein-based organelles that maintain a conserved number and structure across many groups of eukaryotes. Centriole number (two per cells) is tightly regulated; each pre-existing centriole nucleates only one centriole as the cell prepares for division. The structure of centrioles is barrel-shaped, with a nine-fold symmetry of microtubules. This organization of microtubules is essential for the ancestral function of centriole–cilium nucleation. In animal cells, centrioles have gained an additional role: recruiting pericentriolar material (PCM) to form a centrosome. Therefore, it is striking that in animal spermatozoa, the centrioles have a remarkable diversity of structures, where some are so anomalous that they are referred to as atypical centrioles and are barely recognizable. The atypical centriole maintains the ability to form a centrosome and nucleate a new centriole, and therefore reveals the most rudimentary structure that is needed for centriole function. However, the atypical centriole appears to be incapable of forming a cilium. Here, we propose that the diversity in sperm centriole structure is due to rapid evolution in the shape of the spermatozoa head and neck. The enhanced diversity may be driven by a combination of direct selection for novel centriole functions and pleiotropy, which eliminates centriole properties that are dispensable in the spermatozoa function.
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影响因子：
5.8
作者：
Fishman EL;Jo K;Ha A;Royfman R;Zinn A;Krishnamurthy M;Avidor-Reiss T
通讯作者：
Avidor-Reiss T
DOI：
10.1080/11250009509356085
发表时间：
1995-01-01
期刊：
BOLLETTINO DI ZOOLOGIA
影响因子：
--
作者：
Dallai, R;Afzelius, BA;Witalinski, W
通讯作者：
Witalinski, W
影响因子：
9.2
作者：
Khire, Atul;Vizuet, Alberto A.;Avidor-Reiss, Tomer
通讯作者：
Avidor-Reiss, Tomer
影响因子：
3.7
作者：
Immler, Simone;Moore, Harry D. M.;Birkhead, Tim R.
通讯作者：
Birkhead, Tim R.
影响因子：
9.2
作者：
Basiri, Marcus L.;Ha, Andrew;Chadha, Abhishek;Clark, Nicole M.;Polyanovsky, Andrey;Cook, Boaz;Avidor-Reiss, Tomer
通讯作者：
Avidor-Reiss, Tomer