Opportunities and challenges for modelling epidemiological and evolutionary dynamics in a multihost, multiparasite system: Zoonotic hybrid schistosomiasis in West Africa.
Opportunities and challenges for modelling epidemiological and evolutionary dynamics in a multihost, multiparasite system: Zoonotic hybrid schistosomiasis in West Africa.
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DOI：
10.1111/eva.12529
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发表时间：
2018-04
影响因子：
4.1
通讯作者：
Rudge JW
中科院分区：
文献类型：
--
作者：
Borlase A;Webster JP;Rudge JW
多宿主多寄生虫系统是进化和生态动态的，这为阐明其流行病学和设计适当的控制提出了大量的跨学科挑战。寄生虫物种之间杂交和基因渗入的证据正在收集，部分原因是分子诊断和基因组测序的改进。这一点越来越明显的一个主要系统是血吸虫属，血吸虫病是一种具有相当重要的医学和兽医学意义的疾病，最大的负担发生在撒哈拉以南非洲。种间杂交和基因渗入带来了复杂性的增加，超过了多宿主、多寄生虫系统中固有的复杂性，也代表了可以驱动进化的遗传变异的额外来源。这有可能对寄生虫病的控制产生深远的影响，包括但不限于扩大宿主范围、增加传播潜力和改变对药物治疗的反应。在这里，我们提出了具有挑战性的情况下的例子，埃及血吸虫属。在西非，一个涉及多种相互作用的寄生虫和多种最终宿主的系统，在一个人畜共患血吸虫病水库以前没有被认为是重要的地区。我们考虑如何将现有的数学模型框架扩展和适应人畜共患病杂交系统，探索这种模型框架如何利用分子和流行病学数据，以及这带来的复杂性和挑战。我们还强调了这样的数学模型可能带来的机会和价值，以及在我们不断变化的世界中一系列类似的多宿主，多和交叉杂交寄生虫系统。
Multihost multiparasite systems are evolutionarily and ecologically dynamic, which presents substantial trans‐disciplinary challenges for elucidating their epidemiology and designing appropriate control. Evidence for hybridizations and introgressions between parasite species is gathering, in part in line with improvements in molecular diagnostics and genome sequencing. One major system where this is becoming apparent is within the Genus Schistosoma, where schistosomiasis represents a disease of considerable medical and veterinary importance, the greatest burden of which occurs in sub‐Saharan Africa. Interspecific hybridizations and introgressions bring an increased level of complexity over and above that already inherent within multihost, multiparasite systems, also representing an additional source of genetic variation that can drive evolution. This has the potential for profound implications for the control of parasitic diseases, including, but not exclusive to, widening host range, increased transmission potential and altered responses to drug therapy. Here, we present the challenging case example of haematobium group Schistosoma spp. hybrids in West Africa, a system involving multiple interacting parasites and multiple definitive hosts, in a region where zoonotic reservoirs of schistosomiasis were not previously considered to be of importance. We consider how existing mathematical model frameworks for schistosome transmission could be expanded and adapted to zoonotic hybrid systems, exploring how such model frameworks can utilize molecular and epidemiological data, as well as the complexities and challenges this presents. We also highlight the opportunities and value such mathematical models could bring to this and a range of similar multihost, multi and cross‐hybridizing parasites systems in our changing world.
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DOI：
10.4269/ajtmh.1968.17.38
发表时间：
1968-01-01
影响因子：
3.3
作者：
CHEEVER, AW
通讯作者：
CHEEVER, AW
DOI：
10.1086/683173
发表时间：
2015-11
期刊：
The American naturalist
影响因子：
--
作者：
Fenton A;Streicker DG;Petchey OL;Pedersen AB
通讯作者：
Pedersen AB
影响因子：
11.8
作者：
Crellen, Thomas;Walker, Martin;Webster, Joanne P.
通讯作者：
Webster, Joanne P.
影响因子：
4.3
作者：
Castillo-Chavez, Carlos;Feng, Zhilan;Xu, Dashun
通讯作者：
Xu, Dashun
影响因子：
3.2
作者：
Anderson, R. M.;Turner, H. C.;Truscott, J. E.
通讯作者：
Truscott, J. E.