Radical SAM Enzymes in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs).
Radical SAM Enzymes in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs).
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DOI：
10.3389/fchem.2017.00087
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发表时间：
2017
影响因子：
5.5
通讯作者：
Berteau O
中科院分区：
文献类型：
--
作者：
Benjdia A;Balty C;Berteau O
核糖体合成和后修饰肽（Ribosomally-synthesized and post-deletionally modified peptides，RIPPs）是一类庞大而多样的天然产物。它们具有有趣的生物学特性，如抗生素或抗癌活性，使它们对治疗应用具有吸引力。与聚酮化合物和非核糖体肽相反，RIPP衍生自核糖体肽，并且通过不同的酶家族进行后修饰。其中，新兴的自由基SAM酶超家族已被证明发挥了重要作用。这些酶催化广泛的翻译后修饰的形成，其中一些在生命系统或合成化学中没有对应物。自由基SAM酶的研究不仅阐明了生命系统将肽定制为复杂天然产物所使用的前所未有的策略，而且还允许发现新的RiPP家族。在这篇综述中，我们总结了目前的知识自由基SAM酶催化RiPP翻译后修饰，并讨论其机制和日益增长的重要性，特别是在人类微生物群的背景下。
Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large and diverse family of natural products. They possess interesting biological properties such as antibiotic or anticancer activities, making them attractive for therapeutic applications. In contrast to polyketides and non-ribosomal peptides, RiPPs derive from ribosomal peptides and are post-translationally modified by diverse enzyme families. Among them, the emerging superfamily of radical SAM enzymes has been shown to play a major role. These enzymes catalyze the formation of a wide range of post-translational modifications some of them having no counterparts in living systems or synthetic chemistry. The investigation of radical SAM enzymes has not only illuminated unprecedented strategies used by living systems to tailor peptides into complex natural products but has also allowed to uncover novel RiPP families. In this review, we summarize the current knowledge on radical SAM enzymes catalyzing RiPP post-translational modifications and discuss their mechanisms and growing importance notably in the context of the human microbiota.
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影响因子：
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作者：
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DOI：
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发表时间：
2017-06-30
期刊：
The Journal of biological chemistry
影响因子：
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影响因子：
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影响因子：
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