Amateur antigen-presenting cells in the tumor microenvironment.
Amateur antigen-presenting cells in the tumor microenvironment.
复制标题
肿瘤微环境中的业余抗原细胞。
DOI：
10.1002/mc.23354
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发表时间：
2022-03
影响因子：
4.6
通讯作者：
Karam, Sana D.
中科院分区：
文献类型：
--
作者：
Darragh, Laurel B.;Karam, Sana D.
肿瘤抗原的呈现是产生稳健的抗肿瘤免疫增生的关键步骤。 II，但最近的证据表明，在肿瘤微环境（TME）中，PAPC除了能够呈现两个MHC上的肿瘤抗原I和II。 。并建议在设计免疫疗法以增加T细胞启动时采用的新方法。
Presentation of tumor antigens is a critical step in producing a robust antitumor immune response. Classically tumor antigens are thought to be presented to both CD8 and CD4 T cells by professional antigen-presenting cells (pAPCs) like dendritic cells using major histocompatibility complexes (MHC) I and II. But recent evidence suggests that in the tumor microenvironment (TME) cells other than pAPCs are capable of presenting tumor antigens on both MHC I and II. The evidence currently available on tumor antigen presentation by epithelial cells, vascular endothelial cells (VECs), fibroblasts, and cancer cells is reviewed herein. We refer to these cell types in the TME as “amateur” APCs (aAPCs). These aAPCs greatly outnumber pAPCs in the TME and could, potentially, play a significant role in priming an antitumor immune response. This new evidence supports a different perspective on antigen presentation and suggests new approaches that can be taken in designing immunotherapies to increase T cell priming.
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影响因子：
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通讯作者：
LIN, CY
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