Glycotherapy: new advances inspire a reemergence of glycans in medicine.
Glycotherapy: new advances inspire a reemergence of glycans in medicine.
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DOI：
10.1016/j.chembiol.2013.09.010
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发表时间：
2014-01-16
影响因子：
--
通讯作者：
Bertozzi CR
中科院分区：
文献类型：
--
作者：
Hudak JE;Bertozzi CR
世纪初标志着现代医学的曙光，基于聚糖的治疗处于最前沿。然而，随着DNA和蛋白质治疗变得容易获得，聚糖很快就黯然失色。研究和生产结构确定的碳水化合物的新工具和技术的最新发展激发了人们对聚糖治疗应用的新兴趣。本综述重点介绍了过去十年中的进展，这些进展使基于聚糖的治疗回到了医学的前沿，以及推动这些努力的技术。这些包括使用聚糖本身作为治疗分子以及工程蛋白质和细胞表面聚糖以适应临床应用。聚糖疗法为学术、生物制药和医学领域的发展提供了丰富而有前途的前沿。
The beginning of the 20th century marked the dawn of modern medicine with glycan-based therapies at the forefront. However, glycans quickly became overshadowed as DNA- and protein-focused treatments became readily accessible. The recent development of new tools and techniques to study and produce structurally defined carbohydrates has spurred renewed interest in the therapeutic applications of glycans. This review focuses on advances within the past decade that are bringing glycan-based treatments back to the forefront of medicine and the technologies that are driving these efforts. These include the use of glycans themselves as therapeutic molecules as well as engineering protein and cell surface glycans to suit clinical applications. Glycan therapeutics offer a rich and promising frontier for developments in the academic, biopharmaceutical, and medical fields.
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影响因子：
--
作者：
Brinkhous, KM;Smith, HP;Seegers, WH
通讯作者：
Seegers, WH
影响因子：
4.9
作者：
Abian, Olga;Alfonso, Pilar;Sancho, Javier
通讯作者：
Sancho, Javier
DOI：
10.1073/pnas.0710412105
发表时间：
2008-03-04
影响因子：
11.1
作者：
Amano, Koh;Chiba, Yasunori;Narimatsu, Hisashi
通讯作者：
Narimatsu, Hisashi
影响因子：
8.9
作者：
通讯作者：
--
使化学栩栩如生。
影响因子：
48
作者：
Boyce, Michael;Bertozzi, Carolyn R.
通讯作者：
Bertozzi, Carolyn R.