Development of the diaphragm -- a skeletal muscle essential for mammalian respiration.

Development of the diaphragm -- a skeletal muscle essential for mammalian respiration.
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DOI:
10.1111/febs.12274
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发表时间:
2013-09
期刊:
The FEBS journal
影响因子:
--
通讯作者:
Kardon G
Kardon G
中科院分区:
其他
文献类型:
--
作者:
Merrell AJ;Kardon G

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The mammalian diaphragm muscle is essential for respiration, and thus it is among the most critical of the skeletal muscles in the human body. Defects in diaphragm development, leading to congenital diaphragmatic hernias (CDH), are common birth defects and result in severe morbidity or mortality. Given its functional importance and the frequency of congenital defects, an understanding of diaphragm development normally and during herniation is important. We review the current knowledge of the embryological origins of the diaphragm, diaphragm development and morphogenesis, and the genetic and developmental etiology of diaphragm birth defects.
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影响因子: 2
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