Severe acute respiratory disease in American mink experimentally infected with SARS-CoV-2.
Severe acute respiratory disease in American mink experimentally infected with SARS-CoV-2.
复制标题
DOI：
10.1172/jci.insight.159573
复制
发表时间：
2022-11-22
期刊：
影响因子：
8
通讯作者：
Munster, Vincent J.
中科院分区：
文献类型：
--
作者：
Adney, Danielle R.;Lovaglio, Jamie;Schulz, Jonathan E.;Yinda, Claude Kwe;Avanzato, Victoria A.;Haddock, Elaine;Port, Julia R.;Holbrook, Myndi G.;Hanley, Patrick W.;Saturday, Greg;Scott, Dana;Shaia, Carl;Nelson, Andrew M.;Spengler, Jessica R.;Tansey, Cassandra;Cossaboom, Caitlin M.;Wendling, Natalie M.;Martens, Craig;Easley, John;Yap, Seng Wai;Seifert, Stephanie N.;Munster, Vincent J.
An animal model that fully recapitulates severe COVID-19 presentation in humans has been a top priority since the discovery of SARS-CoV-2 in 2019. Although multiple animal models are available for mild to moderate clinical disease, models that develop severe disease are still needed. Mink experimentally infected with SARS-CoV-2 developed severe acute respiratory disease, as evident by clinical respiratory disease, radiological, and histological changes. Virus was detected in nasal, oral, rectal, and fur swabs. Deep sequencing of SARS-CoV-2 from oral swabs and lung tissue samples showed repeated enrichment for a mutation in the gene encoding nonstructural protein 6 in open reading frame 1ab. Together, these data indicate that American mink develop clinical features characteristic of severe COVID-19 and, as such, are uniquely suited to test viral countermeasures.
登录
查看更多内容
DOI：
10.3390/v13040599
发表时间：
2021-04-01
期刊：
Viruses
影响因子：
--
作者：
Holbrook MG;Anthony SJ;Navarrete-Macias I;Bestebroer T;Munster VJ;van Doremalen N
通讯作者：
van Doremalen N
影响因子：
64.8
作者：
Muñoz-Fontela C;Dowling WE;Funnell SGP;Gsell PS;Riveros-Balta AX;Albrecht RA;Andersen H;Baric RS;Carroll MW;Cavaleri M;Qin C;Crozier I;Dallmeier K;de Waal L;de Wit E;Delang L;Dohm E;Duprex WP;Falzarano D;Finch CL;Frieman MB;Graham BS;Gralinski LE;Guilfoyle K;Haagmans BL;Hamilton GA;Hartman AL;Herfst S;Kaptein SJF;Klimstra WB;Knezevic I;Krause PR;Kuhn JH;Le Grand R;Lewis MG;Liu WC;Maisonnasse P;McElroy AK;Munster V;Oreshkova N;Rasmussen AL;Rocha-Pereira J;Rockx B;Rodríguez E;Rogers TF;Salguero FJ;Schotsaert M;Stittelaar KJ;Thibaut HJ;Tseng CT;Vergara-Alert J;Beer M;Brasel T;Chan JFW;García-Sastre A;Neyts J;Perlman S;Reed DS;Richt JA;Roy CJ;Segalés J;Vasan SS;Henao-Restrepo AM;Barouch DH
通讯作者：
Barouch DH
影响因子：
28.2
作者：
Liu, Yuwei;Du, Xuebei;Zhao, Yan
通讯作者：
Zhao, Yan
影响因子：
3.8
作者：
Fukushi, S;Mizutani, T;Morikawa, S
通讯作者：
Morikawa, S
DOI：
10.3390/ani11051422
发表时间：
2021-05-16
期刊：
Animals : an open access journal from MDPI
影响因子：
--
作者：
Aguiló-Gisbert J;Padilla-Blanco M;Lizana V;Maiques E;Muñoz-Baquero M;Chillida-Martínez E;Cardells J;Rubio-Guerri C
通讯作者：
Rubio-Guerri C