First Description of SARS-CoV-2 Infection in Two Feral American Mink (Neovison vison) Caught in the Wild.
First Description of SARS-CoV-2 Infection in Two Feral American Mink (Neovison vison) Caught in the Wild.
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DOI：
10.3390/ani11051422
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发表时间：
2021-05-16
期刊：
影响因子：
--
通讯作者：
Rubio-Guerri C
中科院分区：
文献类型：
--
作者：
Aguiló-Gisbert J;Padilla-Blanco M;Lizana V;Maiques E;Muñoz-Baquero M;Chillida-Martínez E;Cardells J;Rubio-Guerri C
COVID-19是近代历史上最重要的流行病之一。这是一种新出现的传染病，可能来源于动物。几种家养和非家养动物自然易受SARS-CoV-2感染，包括鼬科，其中水貂是第一个被确定患有这种感染的物种。本文报道了在西班牙东部巴伦西亚社区（Valencian Community）的入侵物种诱捕活动中，在两只野生美洲水貂（Neovison vison）的淋巴结组织中检测到SARS-CoV-2 RNA。严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）是COVID-19的致病因子，被认为是一种主要在人与人之间传播的动物源病原体。几种动物物种可自然或实验感染SARS-CoV-2，有令人信服的证据表明水貂对SARS-CoV-2感染高度敏感。已经报告了人-水貂感染病例，也有迹象表明发生了水貂-人感染。迄今为止，只有皮草养殖场报告了水貂感染，除了犹他州（美国）皮草养殖场附近的一只受感染的自由放养野生水貂，这表明有从养殖场到野生水貂的传播途径。我们现在报告，在入侵物种诱捕运动中，在瓦伦西亚社区（西班牙东部）捕获的13只野生深棕色美洲水貂（Neovison vison）中，有2只检测到SARS-CoV-2。它们被困在人烟稀少的农村地区的河床上，那里有自给自足的野生水貂种群。最近的毛皮农场在20公里外。通过两步RT-PCR在这些动物的肠系膜淋巴结中检测到SARS-CoV-2 RNA，并通过对S基因的397个核苷酸扩增区域进行测序来证实，在两只动物中得到相同的序列。对该序列进行分子系统发育分析，发现该序列与武汉SARS-CoV-2的一致序列相对应。我们的发现似乎代表了自给自足种群中野生水貂在野外获得SARS-CoV-2的第一个例子。
COVID-19 is one of the most important pandemics in recent history. It is an emerging infectious disease, probably of animal origin. Several domesticated and non-domesticated animals are naturally susceptible to SARS-CoV-2 infection, including Mustelidae, of which mink is the first species identified to suffer from this infection. We report herein the detection of the SARS-CoV-2 RNA in lymph node tissue from two feral American mink (Neovison vison) trapped in the wild in the Valencian Community (Eastern Spain) during invasive species trapping campaigns. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of COVID-19, is considered a pathogen of animal origin that is mainly transmitted from human to human. Several animal species can be naturally or experimentally infected by SARS-CoV-2, with compelling evidence that mink is highly susceptible to SARS-CoV-2 infection. Human-to-mink infection cases have been reported and there are also suggestions that mink-to-human infection occurs. Mink infections have been reported to date only on fur farms, except for one infected free- ranging wild mink near a Utah (USA) fur farm, which suggests a transmission pathway from farms to wild mink. We now report the detection of SARS-CoV-2 in 2 of 13 feral dark brown American mink (Neovison vison) trapped in the Valencian Community (Eastern Spain), during an invasive species trapping campaign. They were trapped in riverbeds in sparsely inhabited rural areas known to harbor self-sustained feral mink populations. The closest fur farm is about 20 km away. SARS-CoV-2 RNA was detected by two-step RT-PCR in these animals’ mesenteric lymph nodes and was confirmed by sequencing a 397-nucleotide amplified region of the S gene, yielding identical sequences in both animals. A molecular phylogenetic analysis was run on this sequence, which was found to correspond to the consensus SARS-CoV-2 sequence from Wuhan. Our findings appear to represent the first example of SARS-CoV-2 acquired in the wild by feral mink in self-sustained populations.
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影响因子：
11.8
作者：
Garigliany M;Van Laere AS;Clercx C;Giet D;Escriou N;Huon C;van der Werf S;Eloit M;Desmecht D
通讯作者：
Desmecht D
影响因子：
1
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影响因子：
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作者：
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通讯作者：
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影响因子：
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通讯作者：
Bøtner A
影响因子：
--
作者：
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通讯作者：
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