Timing-dependent septal cholinergic induction of dynamic hippocampal synaptic plasticity.
Timing-dependent septal cholinergic induction of dynamic hippocampal synaptic plasticity.
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DOI：
10.1016/j.neuron.2011.04.026
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发表时间：
2011-07-14
期刊：
影响因子：
16.2
通讯作者：
Yakel JL
中科院分区：
文献类型：
--
作者：
Gu Z;Yakel JL
胆碱能调制海马突触可塑性已被广泛研究，通过应用受体激动剂或阻断剂，然而，快速生理胆碱能刺激可塑性的影响在很大程度上是未知的。在这里，我们报告，隔胆碱能输入，激活电刺激或通过光遗传学的方法，诱导不同类型的海马Schaeffer侧支（SC）CA1突触可塑性，这取决于胆碱能输入的时间相对于SC输入。当胆碱能输入在SC刺激前100或10 msec被激活时，它分别导致α7 nAChR依赖性长时程增强（LTP）或短时程抑制。当胆碱能刺激延迟至SC刺激后10毫秒，毒蕈碱AChR依赖性LTP诱导。此外，这些不同形式的可塑性被Aβ暴露破坏。这些结果揭示了胆碱能功能的时间精确性，为胆碱能依赖的高级认知功能的信息加工提供了一种新的机制。
Cholinergic modulation of hippocampal synaptic plasticity has been studied extensively by applying receptor agonists or blockers; however the effect of rapid physiological cholinergic stimuli on plasticity is largely unknown. Here we report that septal cholinergic input, activated either by electrical stimulation or via an optogenetic approach, induced different types of hippocampal Schaeffer collateral (SC) to CA1 synaptic plasticity, depending on the timing of cholinergic input relative to the SC input. When the cholinergic input was activated 100 or 10 msec prior to SC stimulation, it resulted in α7 nAChR-dependent long-term potentiation (LTP) or short-term depression, respectively. When the cholinergic stimulation was delayed until 10 msec after the SC stimulation, a muscarinic AChR-dependent LTP was induced. Moreover, these various forms of plasticity were disrupted by Aβ exposure. These results have revealed the remarkable temporal precision of cholinergic functions, providing a novel mechanism for information processing in cholinergic-dependent higher cognitive functions.
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影响因子：
5.5
作者：
Cobb, SR;Davies, CH
通讯作者：
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影响因子：
16.2
作者：
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DOI：
10.1124/jpet.110.176255
发表时间：
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影响因子：
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通讯作者：
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作者：
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