The ins and outs of cyclic di-GMP signaling in Vibrio cholerae.
The ins and outs of cyclic di-GMP signaling in Vibrio cholerae.
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DOI：
10.1016/j.mib.2017.01.002
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发表时间：
2017-04
影响因子：
5.4
通讯作者：
Yildiz FH
中科院分区：
文献类型：
--
作者：
Conner JG;Zamorano-Sánchez D;Park JH;Sondermann H;Yildiz FH
第二信使核苷酸环二聚体鸟苷单磷酸(c-di-GMP)控制着兼性霍乱弧菌的许多细胞过程。这种生物应对水生环境中不断变化的环境条件，以及在与人类宿主的交接过程中。C-di-GMP的调节允许霍乱弧菌在活动和静止的生命阶段之间转换，从而允许在其传播周期中对应激源和环境条件进行适应。霍乱弧菌基因组编码一大套蛋白质，预计会降解并产生c-di-GMP。这些酶的一个子集已被证明通过转录、转录后和翻译机制控制细胞过程--特别是运动、生物膜形成和毒力。最近的研究已经确定和表征了调节或感觉c-di-GMP水平的酶，并导致了对霍乱弧菌中c-di-GMP调节电路的机械性理解。
The second messenger nucleotide cyclic dimeric guanosine monophosphate (c-di-GMP) governs many cellular processes in the facultative human pathogen Vibrio cholerae. This organism copes with changing environmental conditions in aquatic environments and during transitions to and from human hosts. Modulation of c-di-GMP allows V. cholerae to shift between motile and sessile stages of life, thus allowing adaptation to stressors and environmental conditions during its transmission cycle. The V. cholerae genome encodes a large set of proteins predicted to degrade and produce c-di-GMP. A subset of these enzymes has been demonstrated to control cellular processes – particularly motility, biofilm formation, and virulence – through transcriptional, post-transcriptional, and translational mechanisms. Recent studies have identified and characterized enzymes that modulate or sense c-di-GMP levels and have lead towards mechanistic understanding of c-di-GMP regulatory circuits in V. cholerae.
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