Five approaches to the suppression of SARS-CoV-2 without intensive social distancing.

Five approaches to the suppression of SARS-CoV-2 without intensive social distancing.
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DOI:
10.1098/rspb.2020.3074
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发表时间:
2021-04-28
期刊:
Proceedings. Biological sciences
影响因子:
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通讯作者:
Handel A
Handel A
中科院分区:
其他
文献类型:
--
作者:
Drake JM;Dahlin K;Rohani P;Handel A

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减缓 SARS-CoV-2 传播的最初努力依赖于密集的社会疏远措施,例如关闭学校和工作场所、就地避难令和禁止人员聚集。其他抑制传播的非药物干预措施包括积极发现病例、接触者追踪、检疫、免疫或健康认证以及广泛的个人防护措施。在这里,我们研究了这些替代抑制方法的潜在有效性。我们引入了一个由两个策略不同的数学模型表示的概念框架。我们发现这两种策略可能都是有效的,尽管两者都需要大量的测试并且在相对狭窄的条件范围内工作。研究发现,戴口罩、改善卫生状况和局部降低密度等普遍防护措施可显着提高有针对性的干预措施的有效性。
Initial efforts to mitigate transmission of SARS-CoV-2 relied on intensive social distancing measures such as school and workplace closures, shelter-in-place orders and prohibitions on the gathering of people. Other non-pharmaceutical interventions for suppressing transmission include active case finding, contact tracing, quarantine, immunity or health certification, and a wide range of personal protective measures. Here we investigate the potential effectiveness of these alternative approaches to suppression. We introduce a conceptual framework represented by two mathematical models that differ in strategy. We find both strategies may be effective, although both require extensive testing and work within a relatively narrow range of conditions. Generalized protective measures such as wearing face masks, improved hygiene and local reductions in density are found to significantly increase the effectiveness of targeted interventions.
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