Comparison of factor XII levels in gestational diabetes, fetal macrosomia, and healthy pregnancies.
Comparison of factor XII levels in gestational diabetes, fetal macrosomia, and healthy pregnancies.
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比较妊娠糖尿病，胎儿大量疾病和健康妊娠的第XII含量的比较。
DOI：
10.1186/s12884-020-03455-0
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发表时间：
2020-12-02
影响因子：
3.1
通讯作者：
Gungor M
中科院分区：
文献类型：
--
作者：
Ozbasli E;Takmaz O;Karabuk E;Gungor M
如果不及时发现和治疗，妊娠期糖尿病（GDM）可导致严重的妊娠并发症，如巨大儿、先兆子痫和胎儿/新生儿死亡。许多研究已经检查了GDM的潜在促成因素，包括高凝状态。因子XII（FXII）是一种在正常妊娠期间增加的凝血因子，我们评估了GDM与FXII、FXIIa（活化FXII）和其他凝血参数水平的关系。GDM与巨大儿密切相关，但尚不清楚FXII是否是巨大儿的独立致病因素。在这项前瞻性研究中，在足月分娩时从69名孕妇中采集血液样本，以确定FXII，FXIIa和其他凝血参数的水平。根据结果，妊娠分为GDM、非糖尿病伴巨大儿（M）或健康（C [对照]）。与M组和C组相比，GDM患者的FXII浓度水平显著更高。当比较FXIIa、活化部分凝血活酶时间、凝血酶原时间（PT）和国际标准化比值时，无显著差异。GDM组FXII浓度与母亲孕前体重指数（BMI）和分娩前BMI呈显著负相关。在M组，FXII浓度与新生儿体重和新生儿体重百分位数呈正相关。在妊娠期糖尿病患者中观察到FXII水平增加。应进一步分析凝血参数与GDM之间的关系，以确定GDM的机制和可能的治疗方式。我们的研究已在clinicaltrials.gov（NCT 03583216）上注册。于2018年7月11日注册，
If not detected and treated, gestational diabetes mellitus (GDM) can cause serious pregnancy complications such as macrosomia, preeclampsia, and fetal/neonatal mortality. Many studies have examined underlying contributing factors for GDM, including hypercoagulation. Factor XII (FXII) is a coagulation factor that increases throughout normal pregnancies, and we evaluated the relationship of GDM with FXII, FXIIa (activated FXII), and other coagulation parameter levels. GDM and macrosomia are closely related, but it is not known whether FXII could be an independent causal factor for macrosomia. In this prospective study, blood samples were taken from 69 pregnant women at the time of term delivery to determine levels of FXII, FXIIa, and other coagulation parameters. Based on the results, pregnancies fell into GDM, non-diabetic with macrosomia (M), or healthy (C [control]). FXII concentration levels were significantly higher in GDM patients compared with the M and C groups. There were no significant differences when comparing FXIIa, activated partial thromboplastin time, prothrombin time (PT), and international normalized ratio. The GDM group saw a significant negative correlation between FXII concentrations and maternal pregestational body mass index (BMI) and BMI before delivery. In the M group, a positive correlation was observed between FXII concentrations and newborn weight and newborn weight percentile. An increase in FXII levels was observed in patients with gestational diabetes. Associations between coagulation parameters and GDM should be further analyzed to define the mechanisms of GDM and possible treatment modalities. Our study has been registered at clinicaltrials.gov (NCT03583216). Registered on July 11, 2018,
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影响因子：
4.2
作者：
Zhu Y;Zhang C
通讯作者：
Zhang C
影响因子：
1.1
作者：
Gorar S;Alioglu B;Ademoglu E;Uyar S;Bekdemir H;Candan Z;Saglam B;Koc G;Culha C;Aral Y
通讯作者：
Aral Y
DOI：
10.1007/5584_2019_382
发表时间：
2019-01-01
期刊：
ADVANCES IN BIOMEDICINE
影响因子：
--
作者：
Teliga-Czajkowska, Justyna;Sienko, Jacek;Czajkowski, Krzysztof
通讯作者：
Czajkowski, Krzysztof
影响因子：
3.7
作者：
Kolyadko, Vladimir N.;Lushchekina, Sofya V.;Panteleev, Mikhail A.
通讯作者：
Panteleev, Mikhail A.
影响因子：
3
作者：
Carr, ME
通讯作者：
Carr, ME