A potential role for adjunctive vitamin D therapy in the management of weight gain and metabolic side effects of second-generation antipsychotics.
A potential role for adjunctive vitamin D therapy in the management of weight gain and metabolic side effects of second-generation antipsychotics.
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DOI：
10.1515/jpem.2011.300
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Lee MM
中科院分区：
文献类型：
--
作者：
Nwosu BU;Meltzer B;Maranda L;Ciccarelli C;Reynolds D;Curtis L;King J;Frazier JA;Lee MM
大约20年前推出的第二代抗精神病药物（SGA）越来越多地用于治疗儿童和青少年的精神疾病。在过去十年中，美国儿童和青少年使用这些药物的人数增加了五倍。然而，与这些药物相关的副作用的发生率也平行上升，如肥胖、血脂异常、胰岛素抵抗和糖尿病。尽管这些并发症的严重性及其对国家医疗保健预算的财务影响，但人们既不清楚导致这些副作用的机制，也不清楚解决这些副作用的最佳方法。研究生活方式的改变和药物制剂产生了混合的结果。因此，使用诸如维生素D的药物的临床研究是必要的，所述药物便宜、容易获得、具有低副作用特征，并且具有抵消SGA药物的代谢副作用的机制。维生素D是一种具有骨骼和骨骼外特性的激素原，可能会降低这些代谢副作用的严重程度。其作为SGA药物代谢副作用管理的替代疗法的作用尚未得到充分研究。遏制这些副作用的有效策略将改善接受SGAs的精神疾病青少年的整体健康状况。在此，我们提出了一个试点研究的使用维生素D的患者与SGAs治疗。
Second-generation antipsychotic (SGA) medications introduced about 20 years ago are increasingly used to treat psychiatric illnesses in children and adolescents. There has been a five-fold increase in the use of these medications in U.S. children and adolescents in the past decade. However, there has also been a parallel rise in the incidence of side effects associated with these medications, such as obesity, dyslipidemia, insulin resistance, and diabetes mellitus. Despite the severity of these complications and their financial impact on the national healthcare budget, there is neither a clear understanding of the mechanisms contributing to these side effects nor the best ways to address them. Studies that examined lifestyle modification and pharmaceutical agents have yielded mixed results. Therefore, clinical studies using agents, such as vitamin D, which are inexpensive, readily available, with low side effects profile, and have mechanisms to counteract the metabolic side effects of SGA agents, are warranted. Vitamin D is a prohormone with skeletal and extraskeletal properties that could potentially reduce the severity of these metabolic side effects. Its role as an adjunctive therapy for the management of metabolic side effects of SGA agents has not been adequately studied. Effective strategies to curb these side effects will improve the overall health of youths with psychiatric illnesses who receive SGAs. Herein we present a pilot study on the use of vitamin D in patients on treatment with SGAs.
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