A Voxel-Based Radiographic Analysis Reveals the Biological Character of Proneural-Mesenchymal Transition in Glioblastoma.
A Voxel-Based Radiographic Analysis Reveals the Biological Character of Proneural-Mesenchymal Transition in Glioblastoma.
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基于体素的放射学分析揭示了胶质母细胞瘤原神经间质转化的生物学特征
DOI：
10.3389/fonc.2021.595259
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发表时间：
2021
影响因子：
4.7
通讯作者：
Cai J
中科院分区：
文献类型：
--
作者：
Qi T;Meng X;Wang Z;Wang X;Sun N;Ming J;Ren L;Jiang C;Cai J
前言：神经和间充质亚型是胶质母细胞瘤分类方案中划分最清楚的两类，在胶质母细胞瘤的发生发展过程中，常会出现由前神经型向间充质亚型的转变。分子特征是通过特定的基因组方法来确定的，但放射学在临床上的应用仍有待进一步研究。在这里，我们研究了基底膜在神经前亚型中的形态特征，并结合成像变量进一步展示了标本的存活特征和原神经-间充质转化(PMT)的进展。方法：数据来源于肿瘤影像资料馆(TCIA，http://cancerimagingarchive.net).本研究使用了223个样本的X线影像、临床变量和转录组亚型。基于重叠和基于体素的病变症状图(VLSM)分析，揭示了GBM地形图上的神经和间充质亚型。此外，我们在VLSM确定的区域内和外部进行了生存分析和PMT进展的比较。结果：总基底膜与原、间充质亚型的图像重叠显示两种亚型之间的相关性。通过VLSM分析，证实神经前亚型与左下颞髓质有关，而间充质亚型未发现明显的体素。随后在VLSM确定的区域内和外部的样本之间的比较显示，在总生存期(OS)、肿瘤纯度、上皮-间充质转化(EMT)评分和临床变量方面存在差异。结论：PMT的进展是由放射学方法决定的。VLSM决定区域的GBM样本倾向于具有神经亚型特征。这项研究提供了一个有价值的VLSM决定的区域，相关的好发部位，预后和PMT进展之间的联系，基底膜的地形和分子特征。
Introduction: Proneural and mesenchymal subtypes are the most distinct demarcated categories in classification scheme, and there is often a shift from proneural type to mesenchymal subtype in the progression of glioblastoma (GBM). The molecular characters are determined by specific genomic methods, however, the application of radiography in clinical practice remains to be further studied. Here, we studied the topography features of GBM in proneural subtype, and further demonstrated the survival characteristics and proneural-mesenchymal transition (PMT) progression of samples by combining with the imaging variables. Methods: Data were acquired from The Cancer Imaging Archive (TCIA, http://cancerimagingarchive.net). The radiography image, clinical variables and transcriptome subtype from 223 samples were used in this study. Proneural and mesenchymal subtype on GBM topography based on overlay and Voxel-based lesion-symptom mapping (VLSM) analysis were revealed. Besides, we carried out the comparison of survival analysis and PMT progression in and outside the VLSM-determined area. Results: The overlay of total GBM and separated image of proneural and mesenchymal subtype revealed a correlation of the two subtypes. By VLSM analysis, proneural subtype was confirmed to be related to left inferior temporal medulla, and no significant voxel was found for mesenchymal subtype. The subsequent comparison between samples in and outside the VLSM-determined area showed difference in overall survival (OS) time, tumor purity, epithelial-mesenchymal transition (EMT) score and clinical variables. Conclusions: PMT progression was determined by radiography approach. GBM samples in the VLSM-determined area tended to harbor the signature of proneural subtype. This study provides a valuable VLSM-determined area related to the predilection site, prognosis and PMT progression by the association between GBM topography and molecular characters.
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影响因子：
3.9
作者：
Darlix, Amelie;Deverdun, Jeremy;Duffau, Hugues
通讯作者：
Duffau, Hugues
影响因子：
4.4
作者：
Clark, Kenneth;Vendt, Bruce;Prior, Fred
通讯作者：
Prior, Fred
DOI：
10.1158/1078-0432.ccr-13-3173
发表时间：
2015-03-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Jung HY;Fattet L;Yang J
通讯作者：
Yang J
影响因子：
3.2
作者：
Kimberg, Daniel Y.;Coslett, H. Branch;Schwartz, Myrna F.
通讯作者：
Schwartz, Myrna F.
影响因子：
17.1
作者：
Itakura H;Achrol AS;Mitchell LA;Loya JJ;Liu T;Westbroek EM;Feroze AH;Rodriguez S;Echegaray S;Azad TD;Yeom KW;Napel S;Rubin DL;Chang SD;Harsh GR 4th;Gevaert O
通讯作者：
Gevaert O