Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy.
Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy.
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DOI：
10.3389/fonc.2018.00237
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发表时间：
2018
影响因子：
4.7
通讯作者：
Boussiotis VA
中科院分区：
文献类型：
--
作者：
Le Bourgeois T;Strauss L;Aksoylar HI;Daneshmandi S;Seth P;Patsoukis N;Boussiotis VA
在利用我们的免疫系统对抗癌症方面已经取得了重大进展，主要是通过检查点阻断和T细胞介导的治疗。癌症免疫治疗领域正在迅速发展，但持久的临床效益只发生在一小部分应答患者中。目前认识到，癌症创造了一个抑制性代谢微环境，导致免疫功能无效。代谢是一种常见的细胞特征，尽管在了解肿瘤微环境（TEM）代谢变化在免疫细胞中的有害作用方面取得了重大进展，但关于独特的靶向途径仍有许多需要了解的地方。阐明癌症和免疫细胞代谢谱对于确定TEM内调节代谢重编程的机制至关重要。介导免疫抑制的代谢靶点是维持肿瘤生长的基础，可以用于治疗性地开发提高免疫治疗效果的方法。在这里，我们将强调代谢对肿瘤相关免疫细胞功能的重要性，并将解决关键代谢决定因素的作用，这些决定因素可能是改善肿瘤免疫治疗的治疗干预目标。
There has been significant progress in utilizing our immune system against cancer, mainly by checkpoint blockade and T cell-mediated therapies. The field of cancer immunotherapy is growing rapidly but durable clinical benefits occur only in a small subset of responding patients. It is currently recognized that cancer creates a suppressive metabolic microenvironment, which contributes to ineffective immune function. Metabolism is a common cellular feature, and although there has been significant progress in understanding the detrimental role of metabolic changes of the tumor microenvironment (TEM) in immune cells, there is still much to be learned regarding unique targetable pathways. Elucidation of cancer and immune cell metabolic profiles is critical for identifying mechanisms that regulate metabolic reprogramming within the TEM. Metabolic targets that mediate immunosuppression and are fundamental in sustaining tumor growth can be exploited therapeutically for the development of approaches to increase the efficacy of immunotherapies. Here, we will highlight the importance of metabolism on the function of tumor-associated immune cells and will address the role of key metabolic determinants that might be targets of therapeutic intervention for improvement of tumor immunotherapies.
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影响因子：
64.5
作者：
Chang CH;Curtis JD;Maggi LB Jr;Faubert B;Villarino AV;O'Sullivan D;Huang SC;van der Windt GJ;Blagih J;Qiu J;Weber JD;Pearce EJ;Jones RG;Pearce EL
通讯作者：
Pearce EL
DOI：
10.1073/pnas.1620433114
发表时间：
2017-01-31
影响因子：
11.1
作者：
Chamoto, Kenji;Chowdhury, Partha S.;Honjo, Tasuku
通讯作者：
Honjo, Tasuku
影响因子：
5.4
作者：
Ben-Shoshan, Jeremy;Maysel-Auslender, Sophia;George, Jacob
通讯作者：
George, Jacob
影响因子：
29
作者：
Chatterjee S;Daenthanasanmak A;Chakraborty P;Wyatt MW;Dhar P;Selvam SP;Fu J;Zhang J;Nguyen H;Kang I;Toth K;Al-Homrani M;Husain M;Beeson G;Ball L;Helke K;Husain S;Garrett-Mayer E;Hardiman G;Mehrotra M;Nishimura MI;Beeson CC;Bupp MG;Wu J;Ogretmen B;Paulos CM;Rathmell J;Yu XZ;Mehrotra S
通讯作者：
Mehrotra S
PD-1检查点途径的分子和生化方面。
DOI：
10.1056/nejmra1514296
发表时间：
2016-11-03
期刊：
The New England journal of medicine
影响因子：
--
作者：
Boussiotis VA
通讯作者：
Boussiotis VA