Curcumin: a potential candidate in prevention of cancer via modulation of molecular pathways.
Curcumin: a potential candidate in prevention of cancer via modulation of molecular pathways.
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姜黄素：通过调节分子途径预防癌症的潜在候选者。
DOI：
10.1155/2014/761608
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发表时间：
2014
影响因子：
--
通讯作者：
Khan MA
中科院分区：
文献类型：
--
作者：
Rahmani AH;Al Zohairy MA;Aly SM;Khan MA
就发病率和死亡率而言，癌症是世界上最可怕的疾病。癌症发生和发展的确切原因尚不完全清楚。但人们认为，癌症的发生是由于基因的结构和功能变化。目前基于对抗疗法的癌症治疗方法昂贵，有副作用；也可能改变基因的正常功能。因此，需要一种安全有效的治疗模式来控制癌症的发生和发展。一些药用植物提供了安全、有效和负担得起的药物来控制恶性细胞的进展。药用植物及其成分的重要性在阿育吠陀、乌纳尼医学和各种宗教书籍中都有记载。姜黄素是香料姜黄的重要成分，是预防癌症的另一种方法。早期的研究表明，姜黄素具有抗氧化、抗菌、抗肿瘤的作用，在控制不同疾病方面也有值得注意的作用。本文就姜黄素通过调控多种细胞信号通路和遗传途径预防癌症的化学预防作用作一综述。
Cancer is the most dreadful disease worldwide in terms of morbidity and mortality. The exact cause of cancer development and progression is not fully known. But it is thought that cancer occurs due to the structural and functional changes in the genes. The current approach to cancer treatment based on allopathic is expensive, exhibits side effects; and may also alter the normal functioning of genes. Thus, a safe and effective mode of treatment is needed to control the cancer development and progression. Some medicinal plants provide a safe, effective and affordable remedy to control the progression of malignant cells. The importance of medicinal plants and their constituents has been documented in Ayurveda, Unani medicine, and various religious books. Curcumin, a vital constituent of the spice turmeric, is an alternative approach in the prevention of cancer. Earlier studies have shown the effect of curcumin as an antioxidant, antibacterial, antitumor and it also has a noteworthy role in the control of different diseases. In this review, we summarize the understanding of chemopreventive effects of curcumin in the prevention of cancer via the regulation of various cell signaling and genetic pathways.
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影响因子：
11.2
作者：
Chadalapaka G;Jutooru I;Chintharlapalli S;Papineni S;Smith R 3rd;Li X;Safe S
通讯作者：
Safe S
DOI：
10.1097/cej.0b013e32834ef194
发表时间：
2012-09
期刊：
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
影响因子：
--
作者：
Alexandrow MG;Song LJ;Altiok S;Gray J;Haura EB;Kumar NB
通讯作者：
Kumar NB
影响因子：
3.8
作者：
Asting AG;Carén H;Andersson M;Lönnroth C;Lagerstedt K;Lundholm K
通讯作者：
Lundholm K
DOI：
10.1073/pnas.212519499
发表时间：
2002-10-29
影响因子：
11.1
作者：
Broceño, C;Wilkie, S;Mittnacht, S
通讯作者：
Mittnacht, S
影响因子：
2.9
作者：
AZUINE, MA;BHIDE, SV
通讯作者：
BHIDE, SV