The intraductal approach to the breast: raison d'être.

The intraductal approach to the breast: raison d'être.
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DOI:
10.1186/bcr1410
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发表时间:
2006
期刊:
Breast cancer research : BCR
影响因子:
--
通讯作者:
Love SM
Love SM
中科院分区:
其他
文献类型:
--
作者:
King BL;Love SM

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发现、预测和治疗乳腺癌的机会存在于三个生物学水平:系统地通过血液、整个器官水平和单个乳腺导管小叶结构。这篇综述包括针对导管小叶单位的方法的评估,导管小叶单位是乳腺癌的起始部位。到目前为止的研究表明,每个乳腺存在5到12个独立的导管小叶系统,每个系统都含有由局部和全身过程贡献的复杂细胞液体。访问和询问这些系统的新技术提供了测量乳房微环境和提取生物风险特征的可能性。
Opportunities for the detection, prediction, and treatment of breast cancer exist at three biological levels: systemically via the blood, at the whole organ level, and within the individual ductal lobular structures of the breast. This review covers the evaluation of approaches targeted to the ductal lobular units, where breast cancer begins. Studies to date suggest the presence of 5 to 12 independent ductal lobular systems per breast, each harboring complex cellular fluids contributed by local and systemic processes. New techniques for accessing and interrogating these systems offer the potential to gauge the microenvironment of the breast and distill biological risk profiles.
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