18F-THK5351 PET Imaging in the Behavioral Variant of Frontotemporal Dementia
18F-THK5351 PET Imaging in the Behavioral Variant of Frontotemporal Dementia
复制标题
18F-THK5351 额颞叶痴呆行为变异的 PET 成像
DOI：
--
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Y. Noh
中科院分区：
文献类型：
--
作者：
Gijin Nam;H. Jeong;Jae Myeong Kang;Sang;Seongho Seo;Ha;K. Park;B. Yeon;T. Ido;Dong;Y. Noh
背景与目的行为变异型额颞叶痴呆（behavioralvariantfrontotemporaldementia，bvFTD）是额颞叶痴呆的一种亚型，临床表现为进行性人格和行为改变，伴有社会认知和执行功能的减退。已知bvFTD的病理学为tau蛋白病或TDP-43。我们在临床诊断为bvFTD的患者中分析了18F-THK 5351正电子发射断层扫描（PET）扫描（最近开发的tau PET）。方法48名参与者，包括行为变异型额颞叶痴呆（bvFTD，n=3）、阿尔茨海默病（AD，n=21）和认知正常（NC，n=24），均完成3 T磁共振成像、18F-THK 5351 PET扫描和详细的神经心理学测试。进行逐体素统计分析和基于感兴趣区（ROI）的分析，以评价bvFTD患者中THK的保留。结果在基于体素和基于ROI的分析中，与NC参与者相比，bvFTD患者在前额、内侧额叶、眶额、前扣带回、前颞下和纹状体区域显示出更大的THK保留。在bvFTD患者中观察到左右不对称。有锥体外系症状的患者表现出脑干中更大的THK保留。结论bvFTD患者的THK保留主要分布在额叶、颞叶、前颞叶和纹状体区域，这些区域是已知与bvFTD临床症状相对应的脑区。我们的研究表明，18F-THK 5351 PET成像可能是诊断bvFTD的支持性工具。
Background and Purpose Behavioral variant frontotemporal dementia (bvFTD) is a subtype of frontotemporal dementia, which has clinical symptoms of progressive personality and behavioral changes with deterioration of social cognition and executive functions. The pathology of bvFTD is known to be tauopathy or TDP-43 equally. We analyzed the 18F-THK5351 positron emission tomography (PET) scans, which were recently developed tau PET, in patients with clinically-diagnosed bvFTD. Methods Forty-eight participants, including participants with behavioral variant frontotemporal dementia (bvFTD, n=3), Alzheimer's disease (AD, n=21) and normal cognition (NC, n=24) who completed 3T magnetic resonance images, 18F-THK5351 PET scans, and detailed neuropsychological tests were included in the study. Voxel-wise statistical analysis and region of interest (ROI)-based analyses were performed to evaluate the retention of THK in bvFTD patients. Results In the voxel-based and ROI-based analyses, patients with bvFTD showed greater THK retention in the prefrontal, medial frontal, orbitofrontal, anterior cingulate, insula, anterior inferior temporal and striatum regions compared to NC participants. Left-right asymmetry was noted in the bvFTD patients. A patient with extrapyramidal symptoms showed much greater THK retention in the brainstem. Conclusions The distribution of THK retention in the bvFTD patients was mainly in the frontal, insula, anterior temporal, and striatum regions which are known to be the brain regions corresponding to the clinical symptoms of bvFTD. Our study suggests that 18F-THK5351 PET imaging could be a supportive tool for diagnosis of bvFTD.
影响因子：
6
作者：
Serrano-Pozo, Alberto;Mielke, Matthew L.;Hyman, Bradley T.
通讯作者：
Hyman, Bradley T.
影响因子：
14.5
作者：
Ossenkoppele, Rik;Schonhaut, Daniel R.;Rabinovici, Gil D.
通讯作者：
Rabinovici, Gil D.
影响因子：
14.5
作者：
Rascovsky, Katya;Hodges, John R.;Miller, Bruce L.
通讯作者：
Miller, Bruce L.