The human G-protein beta3 subunit C825T polymorphism is associated with coronary artery vasoconstriction.
The human G-protein beta3 subunit C825T polymorphism is associated with coronary artery vasoconstriction.
复制标题
人 G 蛋白 beta3 亚基 C825T 多态性与冠状动脉血管收缩有关。
DOI：
10.1053/euhj.2000.2400
复制
发表时间：
2001
影响因子：
39.3
通讯作者：
P. Amouyel
中科院分区：
文献类型：
--
作者：
A. Meirhaeghe;C. Bauters;N. Helbecque;Martial Hamon;E. McFadden;J. Lablanche;M. Bertrand;P. Amouyel
目标
AIMS
Abnormal coronary vasomotion plays a role in the clinical expression of coronary artery disease. We hypothesized that the functional C825T polymorphism located in the ubiquitous G-protein beta3 subunit, implicated in the cellular signal transduction of many receptors, could modify artery coronary vasomotion. We assessed the potential association of the pertussis toxin-sensitive G protein beta3 subunit (GNB3) gene C825T polymorphism on coronary vasomotion in humans.
METHODS AND RESULTS
We examined the response of angiographically normal human coronary arteries (n=131) after intravenous injection of methylergonovine maleate, a vasoconstrictor, followed by injection of isosorbide dinitrate, a vasodilator, according to GNB3 genotypes. Coronary vasomotion was assessed with quantitative coronary angiography. Subjects bearing at least one T allele had greater susceptibility to vasoconstriction in response to methylergonovine maleate than CC subjects, whereas vasodilation in response to isosorbide dinitrate did not differ among the different genotypes.
CONCLUSION
The C825T polymorphism of the G-protein beta3 subunit may be a genetic determinant of coronary artery vasomotion in humans.
β3 亚基的分子克隆，β3 亚基是 G 蛋白 β 亚基多肽的第三种形式。
DOI：
10.1073/pnas.87.6.2329
发表时间：
1990
影响因子：
11.1
作者：
Levine,MA;Smallwood,PM;MoenJr,PT;Helman,LJ;Ahn,TG
通讯作者：
Ahn,TG