A mystery unraveled: nontumorigenic pluripotent stem cells in human adult tissues.
A mystery unraveled: nontumorigenic pluripotent stem cells in human adult tissues.
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DOI：
10.1517/14712598.2014.900538
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发表时间：
2014-07
影响因子：
4.6
通讯作者：
Chazenbalk GD
中科院分区：
文献类型：
--
作者：
Simerman AA;Perone MJ;Gimeno ML;Dumesic DA;Chazenbalk GD
胚胎干细胞和诱导多能干细胞已成为多能干细胞的黄金标准，并且是对再生和治疗应用具有最高潜力的干细胞类别;然而，它们的翻译使用通常受到通常与多能性相关的畸胎瘤形成的阻碍。我们讨论了一群非致瘤性多能干细胞，称为多谱系分化应激耐受（Muse）细胞，它为各种人类疾病的潜在治疗提供了一种创新且令人兴奋的探索途径。这篇综述讨论了缪斯细胞的起源，详细描述了它们的各种独特的特性，并考虑了它们的应用和调查方面的未来途径，目前已知的成人多能干细胞在科学文献中。我们开始通过定义细胞潜能，然后讨论间充质和各种报道的多能干细胞群体，最后深入研究Muse细胞和使它们与同时代细胞区分开的特征。来源于脂肪组织的Muse细胞（Muse-AT）有效地、常规地和无痛地从人脂肪抽吸物材料中分离，自发地和在培养基特异性诱导下表现出成三胚层分化，并且不形成畸胎瘤。我们描述了特定于Muse-AT细胞的品质及其对再生医学和细胞治疗领域的潜在影响。
Embryonic stem cells and induced pluripotent stem cells have emerged as the gold standard of pluripotent stem cells and the class of stem cell with the highest potential for contribution to regenerative and therapeutic application; however, their translational use is often impeded by teratoma formation, commonly associated with pluripotency. We discuss a population of nontumorigenic pluripotent stem cells, termed Multilineage Differentiating Stress Enduring (Muse) cells, which offer an innovative and exciting avenue of exploration for the potential treatment of various human diseases. This review discusses the origin of Muse cells, describes in detail their various unique characteristics, and considers future avenues of their application and investigation with respect to what is currently known of adult pluripotent stem cells in scientific literature. We begin by defining cell potency, then discuss both mesenchymal and various reported populations of pluripotent stem cells, and finally delve into Muse cells and the characteristics that set them apart from their contemporaries. Muse cells derived from adipose tissue (Muse-AT) are efficiently, routinely and painlessly isolated from human lipoaspirate material, exhibit tripoblastic differentiation both spontaneously and under media-specific induction, and do not form teratomas. We describe qualities specific to Muse-AT cells and their potential impact on the field of regenerative medicine and cell therapy.
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影响因子：
5.2
作者：
Dayem AA;Choi HY;Kim JH;Cho SG
通讯作者：
Cho SG
影响因子：
3.7
作者：
Chazenbalk G;Bertolotto C;Heneidi S;Jumabay M;Trivax B;Aronowitz J;Yoshimura K;Simmons CF;Dumesic DA;Azziz R
通讯作者：
Azziz R
影响因子：
46.9
作者：
Cunningham, Justine J.;Ulbright, Thomas M.;Looijenga, Leendert H. J.
通讯作者：
Looijenga, Leendert H. J.
影响因子：
120.7
作者：
Engels, Eric A.;Pfeiffer, Ruth M.;Fraumeni, Joseph F., Jr.;Kasiske, Bertram L.;Israni, Ajay K.;Snyder, Jon J.;Wolfe, Robert A.;Goodrich, Nathan P.;Bayakly, A. Rana;Clarke, Christina A.;Copeland, Glenn;Finch, Jack L.;Fleissner, Mary Lou;Goodman, Marc T.;Kahn, Amy;Koch, Lori;Lynch, Charles F.;Madeleine, Margaret M.;Pawlish, Karen;Rao, Chandrika;Williams, Melanie A.;Castenson, David;Curry, Michael;Parsons, Ruth;Fant, Gregory;Lin, Monica
通讯作者：
Lin, Monica
影响因子：
5.3
作者：
Guo, GZ;Yan-Sanders, Y;Li, JJ
通讯作者：
Li, JJ