INI1-negative colorectal undifferentiated carcinoma with rhabdoid features and postoperative rapidly growing liver metastases: a case report and review of the literature.
INI1-negative colorectal undifferentiated carcinoma with rhabdoid features and postoperative rapidly growing liver metastases: a case report and review of the literature.
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伴有横纹肌样特征的INI1阴性未分化结直肠癌和术后快速生长的肝转移：病例报告和文献回顾。
DOI：
10.1186/s40792-021-01189-5
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发表时间：
2021-04-27
影响因子：
0.8
通讯作者：
Tani M
中科院分区：
文献类型：
--
作者：
Kojima M;Miyake T;Ueki T;Ohta H;Kushima R;Shiohara M;Mizuta H;Iida H;Yamaguchi T;Kaida S;Takebayashi K;Maehira H;Nishina Y;Shimizu T;Mekata E;Tani M
恶性肿瘤与横纹肌样特征是非常罕见的。它们可以发生在各种器官，包括胃肠道，具有高度恶性和预后不良的共同临床特征。一位41岁的男性来我院就诊，主诉下腹疼痛和发热。计算机断层扫描（CT）显示直肠和乙状结肠两个壁增厚病变，后者侵犯小肠和腹壁。乙状结肠系膜和肠系膜下动脉根部淋巴结肿大。结肠镜检查显示乙状结肠有一个圆形的3型病变，直肠有一个半圆形的2型病变。乙状结肠和直肠病变活检显示低分化和中等分化的腺癌细胞，分别。切除乙状结肠、直肠、受侵小肠和腹壁;同时进行淋巴结清扫。乙状结肠病变的组织学发现，肿瘤细胞之间的连接性较差，每个细胞的胞浆嗜酸性，核多形。这些特征被称为横纹肌样特征，因为这些细胞的形态与横纹肌肉瘤肿瘤细胞的形态相似。免疫组化检查显示，肿瘤细胞的上皮细胞（细胞角蛋白AE 1/AE 3）和间充质细胞标志物（波形蛋白）阳性，但整合酶相互作用因子1（INI 1）阴性。因此，乙状结肠直肠癌被诊断为具有横纹肌样特征的INI 1阴性未分化癌。患者术后持续高热;因此，我们进行了腹部CT扫描，显示术后4天肝脏囊性病变。这些在术前14天进行的正电子发射断层扫描（PET）-CT扫描中不存在。这些肿瘤生长迅速，细针穿刺细胞学检查显示，它们是未分化癌，与来自乙状结肠的具有横纹肌样特征的未分化癌的转移性病变相一致。给予化疗，但无效。患者于术后60天死亡。具有横纹肌样特征的INI 1阴性结直肠未分化癌非常罕见，组织学恶性度高，预后差。化疗无效。需要有效的全身治疗。
Malignant tumors with rhabdoid features are extremely rare. They can occur in various organs, including the gastrointestinal tract, with common clinical features of high malignancy and poor prognosis. A 41-year-old man visited our hospital complaining of lower abdominal pain and fever. Computed tomography (CT) revealed two wall-thickening lesions in the rectum and sigmoid colon, with the latter invading the small intestine and abdominal wall. Lymph nodes were swollen in the sigmoid mesocolon and at the roots of the inferior mesenteric artery. Colonoscopy revealed a circular type 3 lesion in the sigmoid colon and a semicircular type 2 lesion in the rectum. Biopsies of the sigmoid colon and rectum lesions revealed poorly and moderately differentiated adenocarcinoma cells, respectively. The sigmoid colon, rectum, invaded small intestine, and abdominal wall were resected; lymph node dissection was also performed. Histopathological finding of the sigmoid colon lesion revealed that the tumor cells had poor connectivity with each other, and each cell had eosinophilic cytoplasm and a polymorphic nucleus. These characteristics are termed rhabdoid features, because the morphology of these cells is similar to that of rhabdomyosarcoma tumor cells. Immunohistochemical examination showed that the tumor cells were positive for both epithelial (cytokeratin AE1/AE3) and mesenchymal cell markers (vimentin); however, they were negative for integrase interactor 1 (INI1). Therefore, the sigmoid colorectal cancer was diagnosed as an INI1-negative undifferentiated carcinoma with rhabdoid features. The patient continued to experience high fever after surgery; thus, we performed an abdominal CT scan that revealed cystic lesions in the liver 4 days after surgery. These were absent in the positron emission tomography (PET)-CT scan performed 14 days before surgery. These tumors grew rapidly, and fine needle aspiration cytology revealed that they were undifferentiated carcinomas compatible with metastatic lesions from the undifferentiated carcinoma with rhabdoid features from the sigmoid colon. Chemotherapy was administered but was not effective. The patient died 60 days after surgery. INI1-negative colorectal undifferentiated carcinomas with rhabdoid features are extremely rare, have high histological malignancy, and a poor prognosis. Chemotherapy is not effective. Effective systemic therapy is desired.
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影响因子：
3.9
作者：
Marcus, VA;Viloria, J;Tsao, MS
通讯作者：
Tsao, MS
影响因子：
1
作者：
D'Amico F;Bertacco A;Cesari M;Mescoli C;Caturegli G;Gondolesi G;Cillo U
通讯作者：
Cillo U
盲肠腺癌分化不佳，表现出明显的色鹿糖特征，并结合阑尾粘液性囊这症：文献报告和文献综述。
影响因子：
2.9
作者：
Cho IJ;Kim SS;Min YD;Noh MW;Hong R
通讯作者：
Hong R
DOI：
10.1007/bf01607171
发表时间：
1993-02-01
期刊：
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
影响因子：
--
作者：
CHETTY, R;BHATHAL, PS
通讯作者：
BHATHAL, PS
影响因子：
3.3
作者：
KODET, R;NEWTON, WA;GEHAN, EA
通讯作者：
GEHAN, EA