Poorly differentiated cecal adenocarcinoma showing prominent rhabdoid feature combined with appendiceal mucinous cystadenoma: A case report and review of the literature.
Poorly differentiated cecal adenocarcinoma showing prominent rhabdoid feature combined with appendiceal mucinous cystadenoma: A case report and review of the literature.
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盲肠腺癌分化不佳，表现出明显的色鹿糖特征，并结合阑尾粘液性囊这症：文献报告和文献综述。
DOI：
10.3892/ol.2015.2905
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发表时间：
2015-04
期刊：
影响因子：
2.9
通讯作者：
Hong R
中科院分区：
文献类型：
--
作者：
Cho IJ;Kim SS;Min YD;Noh MW;Hong R
肾外横纹肌样瘤（ERRT）是极其罕见的肿瘤；其中，结直肠 ERRT 最为罕见，之前的英文文献中仅描述了 9 例。本研究报告一例73岁男性低分化盲肠腺癌，横纹肌样特征明显，合并阑尾粘液性囊腺瘤一例的病理特征，并对既往报道的病例进行回顾。镜下观察，肿瘤细胞多数不粘连或松散粘连，形态呈多角形，横纹肌样特征明显，核偏心，呈泡状，核仁明显，胞质丰富，嗜酸性。免疫组织化学显示，肿瘤细胞细胞角蛋白（CK）和波形蛋白呈阳性，但CK20、CK7、结蛋白和平滑肌肌动蛋白呈阴性。这表明诊断为低分化腺癌，具有明显的横纹肌样特征，并伴有阑尾粘液性囊腺瘤。手术后两个月，患者死于腹膜播散以及肝脏和骨骼转移。横纹肌样表型的出现总是与侵袭性且几乎总是致命的临床病程相关。本病例是第10例结肠肿瘤，据我们所知，这是第一例结肠横纹肌样瘤与阑尾良性粘液性肿瘤同时发生的病例。
Extrarenal rhabdoid tumors (ERRTs) are extremely rare neoplasms; of these, colorectal ERRTs are the most rare, and only nine cases have been previously described in the English language literature. The current study reports the pathological features of a case of poorly differentiated cecal adenocarcinoma with prominent rhabdoid feature, which was combined with mucinous cystadenoma of the appendix in a 73-year-old male, and additionally reviews the previously reported cases. Microscopically, the majority of tumor cells were non-cohesive or loosely cohesive, with a polygonal morphology and prominent rhabdoid feature, showing eccentric vesicular nuclei, prominent nucleoli and abundant eosinophilic cytoplasm. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) and vimentin, but negative for CK20, CK7, desmin and smooth muscle actin. This indicated a diagnosis of poorly differentiated adenocarcinoma with prominent rhabdoid features, combined with appendiceal mucinous cystadenoma. At two months following surgery the patient succumbed to peritoneal seeding and metastasis of liver and bone The emergence of the rhabdoid phenotype is invariably associated with an aggressive and almost always fatal clinical course. The present case is the 10th example of such a tumor in the colon, and to the best of our knowledge, this is the first case of colonic rhabdoid tumor coinciding with appendiceal benign mucinous neoplasm.
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影响因子：
3.9
作者：
Marcus, VA;Viloria, J;Tsao, MS
通讯作者：
Tsao, MS
DOI：
10.1007/bf01607171
发表时间：
1993-02-01
期刊：
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
影响因子：
--
作者：
CHETTY, R;BHATHAL, PS
通讯作者：
BHATHAL, PS
影响因子：
3.3
作者：
KODET, R;NEWTON, WA;GEHAN, EA
通讯作者：
GEHAN, EA
影响因子：
1.2
作者：
Remo, Andrea;Zanella, Caterina;Vendraminelli, Roberto
通讯作者：
Vendraminelli, Roberto
影响因子：
1.2
作者：
Kono, Tokuyuki;Imai, Yasuo;Fujimori, Takahiro
通讯作者：
Fujimori, Takahiro