Parabolic avalanche scaling in the synchronization of cortical cell assemblies.
Parabolic avalanche scaling in the synchronization of cortical cell assemblies.
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DOI：
10.1038/s41467-023-37976-x
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发表时间：
2023-05-03
影响因子：
16.6
通讯作者：
Plenz, Dietmar
中科院分区：
文献类型：
--
作者：
Capek, Elliott;Ribeiro, Tiago L.;Kells, Patrick;Srinivasan, Keshav;Miller, Stephanie R.;Geist, Elias;Victor, Mitchell;Vakili, Ali;Pajevic, Sinisa;Chialvo, Dante R.;Plenz, Dietmar
大脑皮层中的神经元在持续的活动过程中和对感觉输入的反应中发出一致的动作电位。这些同步的细胞集合体是皮层功能的基础，但它们的大小和持续时间的基本动力学方面在很大程度上是未知的。使用2-光子成像的神经元在清醒的小鼠的表层皮层，我们发现，同步细胞组装组织规模不变的雪崩，二次增长的持续时间。二次雪崩缩放只发现相关的神经元，需要时间粗粒化，以补偿空间子采样的成像皮层，并建议皮层动力学是至关重要的平衡E/I网络的模拟中所示。指数为χ = 2的倒抛物线的相应时间过程描述了在1 mm 2的面积上持续时间长达5 s的同时放电的皮质雪崩。这些抛物线雪崩最大限度地提高了前额叶和躯体感觉皮层的持续活动和初级视觉皮层的视觉反应的时间复杂性。我们的研究结果确定了一个规模不变的时间顺序同步的高度多样化的皮层细胞组件的形式抛物线雪崩。同步神经元群的多样性对大脑理论提出了挑战。在这里，作者报告说，群体规模与持续时间成二次方增长，这与神经元雪崩和大脑动力学的预测是至关重要的。
Neurons in the cerebral cortex fire coincident action potentials during ongoing activity and in response to sensory inputs. These synchronized cell assemblies are fundamental to cortex function, yet basic dynamical aspects of their size and duration are largely unknown. Using 2-photon imaging of neurons in the superficial cortex of awake mice, we show that synchronized cell assemblies organize as scale-invariant avalanches that quadratically grow with duration. The quadratic avalanche scaling was only found for correlated neurons, required temporal coarse-graining to compensate for spatial subsampling of the imaged cortex, and suggested cortical dynamics to be critical as demonstrated in simulations of balanced E/I-networks. The corresponding time course of an inverted parabola with exponent of χ = 2 described cortical avalanches of coincident firing for up to 5 s duration over an area of 1 mm2. These parabolic avalanches maximized temporal complexity in the ongoing activity of prefrontal and somatosensory cortex and in visual responses of primary visual cortex. Our results identify a scale-invariant temporal order in the synchronization of highly diverse cortical cell assemblies in the form of parabolic avalanches. The diversity of synchronized neuronal groups provides a challenge for brain theories. Here, the authors report that group size grows quadratically with duration in line with predictions for neuronal avalanches and brain dynamics being critical.
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