Acute kidney injury and aging.
Acute kidney injury and aging.
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DOI：
10.1007/s00467-020-04849-0
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Chang-Panesso M
中科院分区：
文献类型：
--
作者：
Chang-Panesso M
我们的老龄化人口正在增长，针对阿尔茨海默氏症和帕金森氏症等与年龄相关的疾病开发治疗方法的紧迫性越来越高，同时公众意识也很高。然而，老年人急性肾损伤(AKI)的发病率已经很高，而且还在不断上升，然而，尽管这个年龄段的AKI发作可能会导致致命的后果，但人们对AKI的关注相对较少。当讨论AKI和衰老时，人们应该考虑两个方面：第一，老年患者对AKI发作的易感性增加，第二，由于AKI进展为慢性肾脏疾病(CKD)的高发，他们在AKI后肾脏修复减少。目前尚不清楚导致AKI易感性增加的相同因素是否在修复能力下降中发挥作用，或者它们是否完全不同且无关。这篇综述将考察目前关于老年人对AKI易感性增加的危险因素的知识，并探索可能导致该年龄段肾脏修复反应降低的潜在方面。
Our aging population is growing and developing treatments for age-related diseases such as Alzheimer’s and Parkinson’s disease has taken on an increasing urgency and is accompanied by high public awareness. The already high and rising incidence of acute kidney injury (AKI) in the elderly, however, has received relatively little attention despite the potentially fatal outcomes associated with an episode of AKI in this age group. When discussing AKI and aging, one should consider two aspects: first, elderly patients have an increased susceptibility to an AKI episode, and second, they have decreased kidney repair after AKI given the high incidence of progression to chronic kidney disease (CKD). It is unclear if the same factors that drive the increased susceptibility to AKI could be playing a role in the decreased repair capacity or if they are totally different and unrelated. This review will examine current knowledge on the risk factors for the increased susceptibility to AKI in the elderly and will also explore potential aspects that might contribute to a decreased kidney repair response in this age group.
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影响因子：
4.6
作者：
Afsar B;Afsar RE;Dagel T;Kaya E;Erus S;Ortiz A;Covic A;Kanbay M
通讯作者：
Kanbay M
影响因子：
64.8
作者：
Baker DJ;Childs BG;Durik M;Wijers ME;Sieben CJ;Zhong J;Saltness RA;Jeganathan KB;Verzosa GC;Pezeshki A;Khazaie K;Miller JD;van Deursen JM
通讯作者：
van Deursen JM
影响因子：
5.9
作者：
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通讯作者：
Chaudhry, Sarwat, I
影响因子：
38.9
作者：
Druml, Wilfred;Lenz, Kurt;Laggner, Anton N.
通讯作者：
Laggner, Anton N.
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J