Understanding how combinations of HLA and KIR genes influence disease.

Understanding how combinations of HLA and KIR genes influence disease.
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DOI:
10.1084/jem.20050499
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发表时间:
2005-04-04
期刊:
The Journal of experimental medicine
影响因子:
--
通讯作者:
Long EO
Long EO
中科院分区:
其他
文献类型:
--
作者:
Rajagopalan S;Long EO

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HLA和杀伤细胞免疫球蛋白样受体(KIR)基因的组合与多种疾病相关,如自身免疫、病毒感染、生殖衰竭和现在的癌症。正如早期观察到疾病与HLA多态性的关联之前,T细胞受体的HLA识别的详细知识,最近报道的疾病与HLA-KIR基因组合乞求更好地了解潜在的机制。
Combinations of HLA and killer cell immunoglobulin–like receptor (KIR) genes have been associated with diseases as diverse as autoimmunity, viral infections, reproductive failure, and now cancer. Much as early observations of disease associations with HLA polymorphism preceded a detailed knowledge of HLA recognition by T cell receptors, the recently reported disease associations with HLA–KIR gene combinations beg for a better understanding of the underlying mechanisms.
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