Are lifestyle-factors in adolescence predictors for adult low back pain? A cross-sectional and prospective study of young twins.
Are lifestyle-factors in adolescence predictors for adult low back pain? A cross-sectional and prospective study of young twins.
复制标题
DOI：
10.1186/1471-2474-7-27
复制
发表时间：
2006-03-15
影响因子：
2.3
通讯作者：
Kyvik KO
中科院分区：
文献类型：
--
作者：
Hestbaek L;Leboeuf-Yde C;Kyvik KO
由于超过一半的人在20岁之前经历过腰痛（LBP），研究必须集中在年轻人身上。生活方式因素可能是预防的重要因素，因为它们本质上是可以改变的。因此，本研究的目的是调查吸烟、饮酒和青春期超重与1)当前腰痛（横断面）和2)未来腰痛风险（纵向）之间的关系。9600对年龄在12-22岁的双胞胎的数据被横断面分析了上述生活方式因素与腰痛之间的关系。8年后，进行了随访调查（n = 6554），随访时的LBP与基线时的生活方式因素相关。最后，在双对照研究设计中对发现的显著关联进行了测试。我们的横断面研究显示，所有三种被调查的生活方式因素与腰痛之间存在很小但有统计学意义的正相关。在纵向研究中，基线吸烟与随访时的LBP呈单调剂量-反应关系（对于每天吸烟20克/天的人，OR高达4.0）。也有暂时性的证据（在LBP之前吸烟）。成人腰痛与青少年饮酒呈负相关。我们没有发现剂量-反应关系或时间性的证据。没有发现青少年超重和成人腰痛之间的联系。在双对照研究中，关联方向相同，但这些关联均未达到统计学意义。布拉德福德希尔的几个因果关系标准在吸烟方面得到了满足，而在饮酒和超重方面，时间性的关键方面却缺失了。这项双对照研究未能证实吸烟与腰痛之间有统计学意义的联系。
With more than half of the population experiencing low back pain (LBP) before the age of 20, research must focus on young populations. Lifestyle-factors might be important elements of prevention, since they are modifiable in nature. Therefore, the objective of the present study is to investigate the association between smoking, alcohol consumption and overweight in adolescence and 1) present LBP (cross-sectionally) and 2) the risk of future LBP (longitudinally). Data from 9,600 twins, aged 12–22, were analysed cross-sectionally with respect to associations between the above-mentioned lifestyle-factors and LBP. Eight years later, a follow-up survey (n = 6,554) was conducted and LBP at follow-up was correlated to the lifestyle-factors at baseline. Finally, the associations found to be significant were tested in a twin-control study design. Our cross-sectional study demonstrated small, but statistically significant, positive associations between all three investigated life-style factors and LBP. In the longitudinal study, smoking at baseline showed a monotonic dose-response relationship with LBP at follow-up (OR up to 4.0 for those smoking >20 cig./day). There was also evidence of temporality (smoking preceding LBP). Adult LBP was negatively associated with adolescent alcohol consumption. We found no evidence of a dose-response relationship or temporality. There were no associations detected between adolescent overweight and adult LBP. In the twin-control study, the directions of associations were the same, but none of these associations attained statistical significance. Several of the Bradford Hill criteria for causality were fulfilled for smoking whereas the crucial aspect of temporality was missing for alcohol consumption and overweight. The twin-control study failed to confirm a statistically significant link between smoking and LBP.
登录
查看更多内容
影响因子：
--
作者：
CHRISTENSEN, K;VAUPEL, JW;YASHIN, AI
通讯作者：
YASHIN, AI
影响因子：
6.3
作者：
LEINO, PI;HANNINEN, V
通讯作者：
HANNINEN, V
影响因子：
7.4
作者：
Peltonen, M;Lindroos, AK;Torgerson, JS
通讯作者：
Torgerson, JS
影响因子：
3.2
作者：
KUORINKA, I;JONSSON, B;JORGENSEN, K
通讯作者：
JORGENSEN, K
影响因子：
3
作者：
Hestbaek, L;Leboeuf-Yde, C;Manniche, C
通讯作者：
Manniche, C