Biodegradable hybrid polymer micelles for combination drug therapy in ovarian cancer.
Biodegradable hybrid polymer micelles for combination drug therapy in ovarian cancer.
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DOI：
10.1016/j.jconrel.2013.04.026
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发表时间：
2013-11-10
期刊：
影响因子：
--
通讯作者：
Bronich TK
中科院分区：
文献类型：
--
作者：
Desale SS;Cohen SM;Zhao Y;Kabanov AV;Bronich TK
The co-delivery of drug combination at a controlled ratioviathe same vehicle to the cancer cells is offering the advantages such as spatial–temporal synchronization of drug exposure, synergistic therapeutic effects and increased therapeutic potency. In an attempt to develop such multidrug vehicle this work focuses on functional biodegradable and biocompatible polypeptide-based polymeric micelles. Triblock copolymers containing the blocks of ethylene glycol, glutamic acid and phenylalanine (PEG–PGlu–PPhe) were successfully synthesizedviaNCA-based ring-opening copolymerization and their composition was confirmed by1H NMR. Self-assembly behavior of PEG–PGlu90–PPhe25was utilized for the synthesis of hybrid micelles with PPhe hydrophobic core, cross-linked ionic PGlu intermediate shell layer, and PEG corona. Cross-linked (cl) micelles were about 90 nm in diameter (ξ-potential = − 20 mV), uniform (narrow size distribution), and exhibited nanogels-like behavior. Degradation ofcl-micelles was observed in the presence of proteolytic enzymes (cathepsin B). The resultingcl-micelles can incorporate the combination of drugs with very different physical properties such as cisplatin (15 w/w% loading) and paclitaxel (9 w/w% loading). Binary drug combination incl-micelles exhibited synergistic cytotoxicity against human ovarian A2780 cancer cells and exerted a superior antitumor activity by comparison to individual drug-loaded micelles or free cisplatin in cancer xenograft modelin vivo. Tunable composition and stability of these hybrid biodegradable micelles provide platform for drug combination delivery in a broad range of cancers.
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DOI：
10.1038/nrc2644
发表时间：
2009-06
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
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影响因子：
11.5
作者：
Batist, Gerald;Gelmon, Karen A.;Louie, Arthur C.
通讯作者：
Louie, Arthur C.
用于卵巢癌靶向治疗的叶酸装饰纳米凝胶。
影响因子：
14
作者：
Nukolova, Natalia V.;Oberoi, Hardeep S.;Cohen, Samuel M.;Kabanov, Alexander V.;Bronich, Tatiana K.
通讯作者：
Bronich, Tatiana K.
影响因子：
8.8
作者：
Sandercock, J;Parmar, MKB;Torri, V;Qian, W
通讯作者：
Qian, W
影响因子：
8
作者：
Oberoi HS;Nukolova NV;Laquer FC;Poluektova LY;Huang J;Alnouti Y;Yokohira M;Arnold LL;Kabanov AV;Cohen SM;Bronich TK
通讯作者：
Bronich TK