The biology of ovarian cancer: new opportunities for translation.

The biology of ovarian cancer: new opportunities for translation.
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DOI:
10.1038/nrc2644
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发表时间:
2009-06
期刊:
Nature reviews. Cancer
影响因子:
--
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其他
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在过去的二十年中,由于更有效的手术和经验优化的细胞毒性药物组合治疗,卵巢癌患者的5年生存率大幅提高,但总体治愈率仍约为30%。许多研究者认为,使用常规药物组合的进一步经验性试验可能只会产生适度的增量改善结果。考虑到这种疾病的异质性,通过将最近在分子和细胞水平上的见解转化为个性化的治疗策略并优化早期检测,可以提高长期生存率。
Over the past two decades, the 5-year survival for ovarian cancer patients has substantially improved owing to more effective surgery and treatment with empirically optimized combinations of cytotoxic drugs, but the overall cure rate remains approximately 30%. Many investigators think that further empirical trials using combinations of conventional agents are likely to produce only modest incremental improvements in outcome. Given the heterogeneity of this disease, increases in long-term survival might be achieved by translating recent insights at the molecular and cellular levels to personalize individual strategies for treatment and to optimize early detection.
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