Chlamydia pneumoniae infection of the central nervous system worsens experimental allergic encephalitis.
Chlamydia pneumoniae infection of the central nervous system worsens experimental allergic encephalitis.
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DOI：
10.1084/jem.20020393
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发表时间：
2002-12-16
期刊：
影响因子：
--
通讯作者：
Sriram S
中科院分区：
文献类型：
--
作者：
Du C;Yao SY;Ljunggren-Rose A;Sriram S
实验性过敏性脑炎（EAE）被许多人认为是人类多发性硬化症的模型。在用神经抗原免疫后，用肺炎衣原体腹膜内接种小鼠，增加了EAE的严重程度。EAE的加重需要活的感染性C。肺炎，疾病的严重程度与抗感染治疗减弱。用神经抗原免疫后，全身感染C。肺炎导致该生物体扩散到具有加重的EAE的小鼠的中枢神经系统（CNS）中。接种沙眼衣原体未加重EAE，CNS中未观察到感染性微生物。这些观察结果表明，C。肺炎导致患有EAE的动物的CNS组织中的局部感染。我们认为C.肺炎克雷伯氏菌可以扩增淋巴细胞的自身反应池并调节自身免疫性疾病的表达。
Experimental allergic encephalitis (EAE) is considered by many to be a model for human multiple sclerosis. Intraperitoneal inoculation of mice with Chlamydia pneumoniae, after immunization with neural antigens, increased the severity of EAE. Accentuation of EAE required live infectious C. pneumoniae, and the severity of the disease was attenuated with antiinfective therapy. After immunization with neural antigens, systemic infection with C. pneumoniae led to the dissemination of the organism into the central nervous system (CNS) in mice with accentuated EAE. Inoculation with Chlamydia trachomatis did not worsen EAE and infectious organisms were not seen in the CNS. These observations suggest that dissemination of C. pneumoniae results in localized infection in CNS tissues in animals with EAE. We propose that infection of the CNS by C. pneumoniae can amplify the autoreactive pool of lymphocytes and regulate the expression of an autoimmune disease.
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影响因子：
4.4
作者：
Du, CG;Khalil, MW;Sriram, S
通讯作者：
Sriram, S
影响因子：
4.8
作者：
Yucesan, C;Sriram, S
通讯作者：
Sriram, S
影响因子：
82.9
作者：
Miller, SD;Vanderlugt, CL;Kim, BS
通讯作者：
Kim, BS
影响因子：
14.5
作者：
Buljevac, D;Flack, HZ;Hintzen, RQ
通讯作者：
Hintzen, RQ
影响因子：
2.4
作者：
Koskiniemi, M;Gencay, M;Havanka, H
通讯作者：
Havanka, H