Verbal learning and hippocampal dysfunction in schizophrenia: A meta-analysis.
Verbal learning and hippocampal dysfunction in schizophrenia: A meta-analysis.
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DOI：
10.1016/j.neubiorev.2017.12.001
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发表时间：
2018-03
影响因子：
8.2
通讯作者：
McGuire P
中科院分区：
文献类型：
--
作者：
Antoniades M;Schoeler T;Radua J;Valli I;Allen P;Kempton MJ;McGuire P
言语学习是精神分裂症患者最严重的认知功能障碍之一。在荟萃分析中纳入未报告的非显著性效应的新方法。言语学习与SCZ海马体积呈正相关。健康对照组中无相关性。本荟萃分析总结了研究语言学习的缺陷是否与精神分裂症患者或有精神分裂症风险的患者和健康对照组的双侧海马体积减少有关。纳入17项研究，755例精神分裂症（SCZ）患者，232例遗传高危（GHR）受试者和914例健康对照（HC）。计算每个诊断组（SCZ、GHR和HC）的半球（左、右或总）与回忆类型（立即或延迟）之间的合并相关系数。在SCZ区，左右海马体积与即刻（r = 0.256，0.230）和延迟（r = 0.132，0.231）言语回忆呈正相关。海马总体积与延迟回忆之间也存在相关性（r = 0.233）。这些相关性在健康对照组中均不显著。GHR组左侧海马体积与即刻回忆呈正相关（r = 0.356）。结果表明，海马体积影响精神分裂症的即时和延迟言语学习能力，并提供了进一步的证据海马功能障碍的病理生理学精神分裂症。
Verbal learning is one of the most impaired cognitive functions in schizophrenia. Novel method for including unreported non-significant effects in the meta-analysis. Positive correlations between verbal learning and hippocampal volume in SCZ. Absent correlations in healthy controls. This meta-analysis summarizes research examining whether deficits in verbal learning are related to bilateral hippocampal volume reductions in patients with or at risk for schizophrenia and in healthy controls. 17 studies with 755 patients with schizophrenia (SCZ), 232 Genetic High Risk (GHR) subjects and 914 healthy controls (HC) were included. Pooled correlation coefficients were calculated between hemisphere (left, right or total) and type of recall (immediate or delayed) for each diagnostic group individually (SCZ, GHR and HC). In SCZ, left and right hippocampal volume positively correlated with immediate (r = 0.256, 0.230) and delayed (r = 0.132, 0.231) verbal recall. There was also a correlation between total hippocampal volume and delayed recall (r = 0.233). None of these correlations were significant in healthy controls. There was however, a positive correlation between left hippocampal volume and immediate recall in the GHR group (r = 0.356). The results suggest that hippocampal volume affects immediate and delayed verbal learning capacity in schizophrenia and provides further evidence of hippocampal dysfunction in the pathophysiology of schizophrenia.
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影响因子：
6.6
作者：
Allen, Paul;Luigjes, Judy;McGuire, Philip
通讯作者：
McGuire, Philip
影响因子：
3.5
作者：
Barha, Cindy K.;Brummelte, Susanne;Galea, Liisa A. M.
通讯作者：
Galea, Liisa A. M.
精神病高风险状态：全面的最新评论。
影响因子：
25.8
作者：
Fusar-Poli, Paolo;Borgwardt, Stefan;Bechdolf, Andreas;Addington, Jean;Riecher-Rossler, Anita;Schultze-Lutter, Frauke;Keshavan, Matcheri;Wood, Stephen;Ruhrmann, Stephan;Seidman, Larry J.;Valmaggia, Lucia;Cannon, Tyrone;Velthorst, Eva;De Haan, Lieuwe;Cornblatt, Barbara;Bonoldi, Ilaria;Birchwood, Max;McGlashan, Thomas;Carpenter, William;McGorry, Patrick;Klosterkotter, Joachim;McGuire, Philip;Yung, Alison
通讯作者：
Yung, Alison
影响因子：
2.5
作者：
Davachi, L;Wagner, AD
通讯作者：
Wagner, AD
影响因子：
6.6
作者：
Bora, Emre;Murray, Robin M.
通讯作者：
Murray, Robin M.