The psychosis high-risk state: a comprehensive state-of-the-art review.
The psychosis high-risk state: a comprehensive state-of-the-art review.
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精神病高风险状态：全面的最新评论。
DOI：
10.1001/jamapsychiatry.2013.269
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发表时间：
2013-01
期刊：
影响因子：
25.8
通讯作者：
Yung, Alison
中科院分区：
文献类型：
--
作者：
Fusar-Poli, Paolo;Borgwardt, Stefan;Bechdolf, Andreas;Addington, Jean;Riecher-Rossler, Anita;Schultze-Lutter, Frauke;Keshavan, Matcheri;Wood, Stephen;Ruhrmann, Stephan;Seidman, Larry J.;Valmaggia, Lucia;Cannon, Tyrone;Velthorst, Eva;De Haan, Lieuwe;Cornblatt, Barbara;Bonoldi, Ilaria;Birchwood, Max;McGlashan, Thomas;Carpenter, William;McGorry, Patrick;Klosterkotter, Joachim;McGuire, Philip;Yung, Alison
在过去的20年里，精神障碍的临床特征发生了重大转变。精神病临床高危(HR)状态的构建已经演变为捕捉精神病前期，描述呈现潜在前驱症状的人。这种HR状态的重要性已经被越来越多地认识到，以至于一种新的综合征被认为是DSM-5中的一个诊断类别。在对已取得的进展进行全面的最先进审查的同时，也认识到仍然存在的挑战，以重新确定人力资源状况。从PubMed、书籍、会议、摘要和国际会议获得过去20年的人力资源研究。对人力资源研究的历史发展、纳入标准、流行病学研究、过渡标准、结果、临床和功能特征、神经认知、神经成像、精神病发展的预测因素、治疗试验、社会经济方面、病因学以及该领域未来的挑战进行了严格的回顾。该领域的一大批世界主要专家讨论了在文献搜索中检索到的相关文章。核心成果是在协商一致后提出的，并以说明性的表格和数字加以总结。相对较新的精神病人力资源研究领域令人振奋。它有可能揭示主要精神障碍的发展并改变它们的进程。它还为向以前无法获得帮助的需要帮助的人提供服务提供了理由，并为那些易患精神病的人提供了改变轨迹的可能性。
During the past 2 decades, a major transition in the clinical characterization of psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for psychosis has evolved to capture the prepsychotic phase, describing people presenting with potentially prodromal symptoms. The importance of this HR state has been increasingly recognized to such an extent that a new syndrome is being considered as a diagnostic category in the DSM-5. To reframe the HR state in a comprehensive state-of-the-art review on the progress that has been made while also recognizing the challenges that remain. Available HR research of the past 20 years from PubMed, books, meetings, abstracts, and international conferences. Critical review of HR studies addressing historical development, inclusion criteria, epidemiologic research, transition criteria, outcomes, clinical and functional characteristics, neurocognition, neuroimaging, predictors of psychosis development, treatment trials, socioeconomic aspects, nosography, and future challenges in the field. Relevant articles retrieved in the literature search were discussed by a large group of leading worldwide experts in the field. The core results are presented after consensus and are summarized in illustrative tables and figures. The relatively new field of HR research in psychosis is exciting. It has the potential to shed light on the development of major psychotic disorders and to alter their course. It also provides a rationale for service provision to those in need of help who could not previously access it and the possibility of changing trajectories for those with vulnerability to psychotic illnesses.
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DOI：
10.1176/appi.ajp.2011.10081209
发表时间：
2011-08
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Carrión RE;Goldberg TE;McLaughlin D;Auther AM;Correll CU;Cornblatt BA
通讯作者：
Cornblatt BA
影响因子：
4.5
作者：
Drake, Richard J.;Lewis, Shon W.
通讯作者：
Lewis, Shon W.
影响因子：
--
作者：
Amminger, G. Paul;Schafer, Miriam R.;Berger, Gregor E.
通讯作者：
Berger, Gregor E.
影响因子：
6.6
作者：
Cornblatt, BA;Lencz, T;Nakayama, E
通讯作者：
Nakayama, E
影响因子：
--
作者：
Fusar-Poli, P.;Stone, J. M.;McGuire, P. K.
通讯作者：
McGuire, P. K.