Appreciating force and shape—the rise of mechanotransduction in cell biology.

Appreciating force and shape—the rise of mechanotransduction in cell biology.
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DOI:
10.1038/nrm3903
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发表时间:
2014-12
影响因子:
112.7
通讯作者:
Sheetz, Michael P.
Sheetz, Michael P.
中科院分区:
生物学1区
文献类型:
--
作者:
Iskratsch, Thomas;Wolfenson, Haguy;Sheetz, Michael P.

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虽然生物体的形状在其基因组中编码,但导致脊椎动物最终形式的发育过程涉及动态机械力与细胞生长和运动之间的持续反馈。机械生物学已经成为一门致力于研究机械力和几何形状对细胞生长和运动性的影响的学科-例如,在细胞-基质粘附发育期间-通过机械转导的信号传导过程。
Although the shapes of organisms are encoded in their genome, the developmental processes that lead to the final form of vertebrates involve a constant feedback between dynamic mechanical forces, and cell growth and motility. Mechanobiology has emerged as a discipline dedicated to the study of the effects of mechanical forces and geometry on cell growth and motility — for example, during cell–matrix adhesion development — through the signalling process of mechanotransduction.
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