Intestinal Permeability Biomarker Zonulin is Elevated in Healthy Aging.
Intestinal Permeability Biomarker Zonulin is Elevated in Healthy Aging.
复制标题
DOI：
10.1016/j.jamda.2017.05.018
复制
发表时间：
2017-09-01
影响因子：
7.6
通讯作者：
Buford TW
中科院分区：
文献类型：
--
作者：
Qi Y;Goel R;Kim S;Richards EM;Carter CS;Pepine CJ;Raizada MK;Buford TW
肠道通透性增加（“漏肠”）被认为是与年龄相关的炎症和肠道生态失调的潜在因素。然而，关于肠道渗漏与衰老过程中炎症和身体虚弱之间关系的信息是有限的。研究衰老相关的肠漏与衰老相关的炎症和虚弱有关的假设。研究了两组健康成人：年轻人（18 - 30岁，n=19）和老年人（≥70岁，n=18）。测定血清TNF-α、il - 6、zonulin（漏肠标志物）和高迁移率群盒蛋白（HMGB1，引发炎症的核蛋白）的浓度。分析血清zonulin和HMGB1水平与足底屈肌强度和每日步行步数的相关性。老年人血清zonulin和HMGB1浓度分别比年轻人高22% （p = 0.005）和16% （p = 0.010）。血清zonulin与TNF-α (r=0.357, p=0.032)、il - 6 （r=0.345, p=0.043）呈正相关。重要的是，zonulin和HMGB1与骨骼肌力量（zonulin: r=−0.332,p=0.048; HMGB1: r=−0.383,p=0.023）和习惯性体育活动（zonulin: r=−0.410,p=0.016; HMGB1: r=−0.483,p=0.004）呈负相关。血清zonulin与全身炎症和身体虚弱的两个关键指标有关。这些数据表明，肠道渗漏可能在与年龄相关的炎症和虚弱的发展中发挥关键作用。
Increased gut permeability (“leaky gut”) has been proposed as a potential contributor to age-related inflammation and gut dysbiosis. However, information on the relationship between a leaky gut and inflammation and physical frailty during aging are limited. To investigate the hypothesis that an aging-associated leaky gut is linked to the age-related inflammation and frailty. Two cohorts of healthy adults were studied: young (18–30-years-old, n=19) and older (≥70-years-old, n=18). Serum concentrations of the TNF-α and IL6, zonulin (a marker for leaky gut) and high-mobility group box protein (HMGB1, a nuclear protein triggering inflammation) were measured. Correlations of serum levels of zonulin and HMGB1 with strength of plantar flexor muscles and number of steps taken per day were analyzed. Serum concentration of zonulin and HMGB1 were 22% (p = 0.005) and 16% (p = 0.010) higher in the older vs young adults. Serum zonulin was positively associated with the concentrations of the TNF-α (r=0.357, p=0.032) and IL6 (r=0.345, p=0.043). Importantly, both zonulin and HMGB1 were negatively correlated with skeletal muscle strength (zonulin: r=−0.332, p=0.048; HMGB1: r=−0.383, p=0.023) and habitual physical activity (zonulin: r=−0.410, p=0.016; HMGB1: r=−0.483, p=0.004). Serum zonulin was associated with both systemic inflammation and two key indices of physical frailty. These data suggest that a leaky gut may play a critical role in the development of age-related inflammation and frailty.
登录
查看更多内容
影响因子：
3.7
作者：
Biagi E;Nylund L;Candela M;Ostan R;Bucci L;Pini E;Nikkïla J;Monti D;Satokari R;Franceschi C;Brigidi P;De Vos W
通讯作者：
De Vos W
影响因子：
3.3
作者：
Buford, Thomas W.;MacNeil, R. Gavin;Leeuwenburgh, Christiaan
通讯作者：
Leeuwenburgh, Christiaan
影响因子：
4.2
作者：
Cattaneo, Annamaria;Cattane, Nadia;Frisoni, Giovanni B.
通讯作者：
Frisoni, Giovanni B.
DOI：
10.1038/ismej.2015.88
发表时间：
2016-01
期刊：
The ISME journal
影响因子：
--
作者：
Jeffery IB;Lynch DB;O'Toole PW
通讯作者：
O'Toole PW
DOI：
10.1093/gerona/glr101
发表时间：
2011-10-01
影响因子：
5.1
作者：
Mackey, Dawn C.;Manini, Todd M.;Cummings, Steven R.
通讯作者：
Cummings, Steven R.