Metabolites involved in purine degradation, insulin resistance, and fatty acid oxidation are associated with prediction of Gestational diabetes in plasma.
Metabolites involved in purine degradation, insulin resistance, and fatty acid oxidation are associated with prediction of Gestational diabetes in plasma.
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DOI：
10.1007/s11306-021-01857-5
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发表时间：
2021-11-27
期刊：
影响因子：
--
通讯作者：
La Frano MR
中科院分区：
文献类型：
--
作者：
McMichael LE;Heath H;Johnson CM;Fanter R;Alarcon N;Quintana-Diaz A;Pilolla K;Schaffner A;Jelalian E;Wing RR;Brito A;Phelan S;La Frano MR
妊娠期糖尿病（GDM）显著增加母亲和胎儿的健康风险，但GDM的预测因素知之甚少。在妊娠早期进行血浆代谢组学分析，以确定与预测妊娠期糖尿病（GDM）相关的潜在代谢物。68名超重/肥胖的孕妇从一个生活方式干预的临床试验。发生GDM的受试者（n=34; GDM组）在治疗组、年龄、体重指数和种族方面与未发生GDM的受试者（n=34;非GDM组）相匹配。在妊娠早期（10-16周）完成抽血。使用三种代谢组学试验通过UPLC-MS分析血浆样品。鉴定了130个部分。当比较GDM组与非GDM组时，包括参与尿酸代谢的嘧啶/嘌呤衍生物、羧酸、脂肪酰基肉毒碱和鞘磷脂（SM）的十三种代谢物是不同的（p<0.05）。GDM患者中最显著的差异是代谢产物次黄嘌呤、黄嘌呤和α-羟基丁酸的升高（p<0.002，校正p<0.02）。由SM 14：0、次黄嘌呤、α-羟基丁酸酯和黄嘌呤四种代谢物组成的组显示出最高的诊断准确性，AUC= 0.833（95% CI：0.572686-0.893946），归类为“非常好的组”。血浆代谢产物主要参与嘌呤降解、胰岛素抵抗和脂肪酸氧化，在妊娠早期与随后的GDM发展有关。
Gestational diabetes mellitus (GDM) significantly increases maternal and fetal health risks, but factors predictive of GDM are poorly understood. Plasma metabolomics analyses were conducted in early pregnancy to identify potential metabolites associated with prediction of Gestational Diabetes Mellitus (GDM). Sixty-eight pregnant women with overweight/obesity from a clinical trial of a lifestyle intervention were included. Participants who developed GDM (n=34; GDM group) were matched on treatment group, age, body mass index, and ethnicity with those who did not develop GDM (n=34; Non-GDM group). Blood draws were completed early in pregnancy (10-16 weeks). Plasma samples were analyzed by UPLC-MS using three metabolomics assays. One hundred thirty moieties were identified. Thirteen metabolites including pyrimidine/purine derivatives involved in uric acid metabolism, carboxylic acids, fatty acylcarnitines, and sphingomyelins (SM) were different when comparing the GDM vs. the Non-GDM groups (p<0.05). The most significant differences were elevations in the metabolites’ hypoxanthine, xanthine and alpha-hydroxybutyrate (p<0.002, adjusted p<0.02) in GDM patients. A panel consisting of four metabolites: SM 14:0, hypoxanthine, alpha-hydroxybutyrate, and xanthine presented the highest diagnostic accuracy with an AUC= 0.833 (95% CI: 0.572686-0.893946), classifying as a “very good panel”. Plasma metabolites mainly involved in purine degradation, insulin resistance, and fatty acid oxidation, were altered in early pregnancy in connection with subsequent GDM development.
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影响因子：
81.5
作者：
McIntyre, H. David;Catalano, Patrick;Damm, Peter
通讯作者：
Damm, Peter
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
DOI：
10.1136/bmj.i969
发表时间：
2016-02-25
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Pearce N
通讯作者：
Pearce N
影响因子：
16.2
作者：
Buchanan, Thomas A.;Xiang, Anny;Watanabe, Richard
通讯作者：
Watanabe, Richard
影响因子：
5
作者：
Law, Kai P.;Han, Ting-Li;Zhang, Hua
通讯作者：
Zhang, Hua