APM1 gene variants -11377C/G and 4545G/C are associated respectively with obesity and with non-obesity in Chinese type 2 diabetes.
APM1 gene variants -11377C/G and 4545G/C are associated respectively with obesity and with non-obesity in Chinese type 2 diabetes.
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APM1基因变异-11377C/G和4545G/C分别与中国2型糖尿病的肥胖和非肥胖相关。
DOI：
10.1016/j.diabres.2009.03.004
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发表时间：
2009-06
影响因子：
5.1
通讯作者：
Shuguang Chi
中科院分区：
文献类型：
--
作者：
Cailian Lan;Sizhong Zhang;Wei Zhang;Yuanzhong Chen;Suyun Chen;Hekun Liu;Xuexiang Chen;Xizhen Wang;Shuguang Chi
为了探讨非肥胖和肥胖2型糖尿病的不同遗传背景，我们尝试通过PCR-RFLP对338例2型糖尿病（T2 D）患者和460例非糖尿病受试者的脂肪最丰富基因转录本1（APM 1）基因中的6个SNP（− 11391 G/A、− 11377 C/G、− 10068 G/A、G54 V、Y111 H和4545 G/C）进行分型。在这些突变中，4545 G/C突变（rs 1063539）与非肥胖组T2 D的遗传风险有关（OR=2.34，95%CI：1.31-4.21，P=0.004），57%的风险与该多态性有关。相反，− 11377 C/G（rs 266729）仅与肥胖组的2型糖尿病相关（OR=2.45，95%CI：1.13-5.31，P=0.02），59%的糖尿病肥胖风险可归因于此。在非条件Logistic回归中，对上述所有关联进行了年龄和性别调整。此外，− 11377 G/4545 C单倍型仅与肥胖糖尿病相关（OR=2.12，95%CI：1.08-4.14，P=0.03）。肥胖糖尿病组甘油三酯、胰岛素水平显著高于非肥胖组，β细胞功能较好，血糖水平较低（P均<0.01）。本研究提示，中国汉族人群中2型糖尿病伴肥胖者与不伴肥胖者的遗传易感性存在差异。
In order to explore the different genetic backgrounds of non-obese and obese type 2 diabetes, we tried to genotype six SNPs (−11391G/A, −11377C/G, −10068G/A, G54V, Y111H and 4545G/C) in the adipose most abundant gene transcript-1 (APM1) gene in 338 type 2 diabetes (T2D) patients and 460 non-diabetic subjects by PCR–RFLP. Among these mutations, the 4545G/C mutation (rs1063539) contributed to the genetic risk of T2D in the non-obese group (OR=2.34, 95%CI: 1.31–4.21, P=0.004), and 57% of the risk is related to this polymorphism. On the contrary, −11377C/G (rs266729) was associated with type 2 diabetes in the obese group only (OR=2.45, 95%CI: 1.13–5.31, P=0.02), and 59% risk of diabesity could be attributed to that. All the associations above were adjusted for age and gender in unconditional logistic regression. Besides, the −11377G/4545C haplotype was merely related to obese diabetes (OR=2.12, 95%CI: 1.08–4.14, P=0.03). In addition, the obese diabetic group had significantly higher levels of triglyceride and insulin, better beta-cell function but lower glucose levels than the non-obese group (all P values <0.01). This study suggests that the genetic susceptibility is different between type 2 diabetes with and without obesity in Chinese Han population.
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影响因子：
44.1
作者：
Shi, YY;He, L
通讯作者：
He, L
影响因子：
--
作者：
Cauchi S;Nead KT;Choquet H;Horber F;Potoczna N;Balkau B;Marre M;Charpentier G;Froguel P;Meyre D
通讯作者：
Meyre D
影响因子：
7.1
作者：
Jang, Y;Lee, JH;Ordovas, JM
通讯作者：
Ordovas, JM
影响因子：
9.8
作者：
Di Paola, R;Frittitta, L;Trischitta, V
通讯作者：
Trischitta, V
影响因子：
7.7
作者：
Gu, HF;Abulaiti, A;Efendic, S
通讯作者：
Efendic, S