Active Mechanisms of Vibration Encoding and Frequency Filtering in Central Mechanosensory Neurons.
Active Mechanisms of Vibration Encoding and Frequency Filtering in Central Mechanosensory Neurons.
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中枢机械感觉神经元振动编码和频率过滤的主动机制。
DOI：
10.1016/j.neuron.2017.09.004
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发表时间：
2017-10-11
期刊：
影响因子：
16.2
通讯作者：
Wilson RI
中科院分区：
文献类型：
--
作者：
Azevedo AW;Wilson RI
为了更好地理解机械感觉加工的生物物理机制，我们研究了果蝇大脑中的两种细胞类型（A2和B1细胞），它们是突触后到触角振动受体的细胞。A2细胞接受兴奋性突触电流，以响应两个方向的运动-因此每个振动周期两次。膜作为一个低通滤波器，使电压和尖峰主要跟踪振动包络，而不是个别周期。相比之下，B1细胞只会被向前或向后的运动激发，这意味着它们对振动相位很敏感。它们接收刺激频率的突触振荡电流，并对这些输入进行带通滤波，使其更倾向于特定的频率。不同的电池偏爱不同的频率，因为它们的电压门控电导不同。Na+和K+电导都抑制低频突触输入，因此具有较大电压门控电导的细胞更倾向于高频。这些结果说明了膜特性和电压门控电导如何将不同的刺激特征提取到平行通道中。
To better understand biophysical mechanisms of mechanosensory processing, we investigated two cell types in the Drosophila brain (A2 and B1 cells) that are postsynaptic to antennal vibration receptors. A2 cells receive excitatory synaptic currents in response to both directions of movement – thus twice per vibration cycle. The membrane acts as a lowpass-filter, so that voltage and spiking mainly track the vibration envelope rather than individual cycles. By contrast, B1 cells are excited by only forward or backward movement, meaning they are sensitive to vibration phase. They receive oscillatory synaptic currents at the stimulus frequency, and they bandpass-filter these inputs to favor specific frequencies. Different cells prefer different frequencies, due to differences in their voltage-gated conductances. Both Na+ and K+ conductances suppress low-frequency synaptic inputs, so cells with larger voltage-gated conductances prefer higher frequencies. These results illustrate how membrane properties and voltage-gated conductances can extract distinct stimulus features into parallel channels.
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影响因子：
2.8
作者：
Budick, Seth A.;Reiser, Michael B.;Dickinson, Michael H.
通讯作者：
Dickinson, Michael H.
影响因子：
3
作者：
Goodman, MB;Lockery, SR
通讯作者：
Lockery, SR
DOI：
10.1073/pnas.130200797
发表时间：
2000-07-05
影响因子：
11.1
作者：
Azouz, R;Gray, CM
通讯作者：
Gray, CM
影响因子：
16.2
作者：
Clemens, Jan;Girardin, Cyrille C.;Murthy, Mala
通讯作者：
Murthy, Mala
影响因子：
7.7
作者：
Hampel, Stefanie;Franconville, Romain;Seeds, Andrew M.
通讯作者：
Seeds, Andrew M.