A novel system for cloning human TCRs: Cutting short the way to TCR-based anticancer therapy.
A novel system for cloning human TCRs: Cutting short the way to TCR-based anticancer therapy.
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DOI:
10.4161/onci.27258
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发表时间:
2014-01-01
期刊:
影响因子:
7.2
通讯作者:
Muraguchi A
中科院分区:
文献类型:
--
作者:
Kobayashi E;Kishi H;Muraguchi A
T-cell receptor (TCR)-based gene immunotherapy has emerged as a promising approach for the treatment of multiple malignancies. We have recently reported an efficient system for the cloning and functional evaluation of TCR-coding cDNAs. This system, which we named hTEC10, allows for the determination of TCR antigen specificity in less than 10 days, and may therefore constitute a fast and powerful platform for the development of new TCR-based anticancer therapies.
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