Cortical Volume, Thickness, and Surface Area in the Motoric Cognitive Risk Syndrome.
Cortical Volume, Thickness, and Surface Area in the Motoric Cognitive Risk Syndrome.
复制标题
运动认知风险综合征中的皮质体积、厚度和表面积。
DOI：
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
J. Verghese
中科院分区：
文献类型：
--
作者：
H. Blumen;Emily Schwartz;G. Allali;O. Beauchet;M. Callisaya;T. Doi;H. Shimada;V. Srikanth;J. Verghese
背景
运动性认知风险(MCR)综合征是痴呆的临床前阶段，以步态缓慢和认知主诉为特征。然而，MCR的大脑基础还没有很好地建立起来。
客观化
在MCR-神经成像联盟中检查与MCR相关的皮质厚度、体积和表面积，该联盟协调多个队列的图像处理/分析。
方法
对来自4个不同队列(各50个)的200例磁共振成像(男性年龄72.62岁；女性47.74%；MCR 33.17%)首先用freesurfer 6.0进行处理，然后对1000个自举样本(n-1；重采样)进行多元和单变量的一般线性模型分析。所有模型都根据年龄、性别、教育程度、脑白质病变、颅内总体积和研究地点进行了调整。
结果
总体而言，有MCR的个体的皮质厚度低于没有MCR的个体。皮质体积也有相同的趋势(p = 0.051)。在前额叶、岛叶、颞叶和顶叶区域，有MCR的个体的局部皮质厚度也低于没有MCR的个体。
结论
MCR中的皮质萎缩是普遍存在的，包括以前与人类运动相关的区域，但也包括社交、认知、情感和运动功能。MCR的皮质萎缩在皮质厚度上比体积和表面积更容易发现，因为厚度更受健康和病理老化的影响。
BACKGROUND
The motoric cognitive risk (MCR) syndrome is a pre-clinical stage of dementia characterized by slow gait and cognitive complaint. Yet, the brain substrates of MCR are not well established.
OBJECTIVE
To examine cortical thickness, volume, and surface area associated with MCR in the MCR-Neuroimaging Consortium, which harmonizes image processing/analysis of multiple cohorts.
METHODS
Two-hundred MRIs (M age 72.62 years; 47.74%female; 33.17%MCR) from four different cohorts (50 each) were first processed with FreeSurfer 6.0, and then analyzed using multivariate and univariate general linear models with 1,000 bootstrapped samples (n-1; with resampling). All models adjusted for age, sex, education, white matter lesions, total intracranial volume, and study site.
RESULTS
Overall, cortical thickness was lower in individuals with MCR than in those without MCR. There was a trend in the same direction for cortical volume (p = 0.051). Regional cortical thickness was also lower among individuals with MCR than individuals without MCR in prefrontal, insular, temporal, and parietal regions.
CONCLUSION
Cortical atrophy in MCR is pervasive, and include regions previously associated with human locomotion, but also social, cognitive, affective, and motor functions. Cortical atrophy in MCR is easier to detect in cortical thickness than volume and surface area because thickness is more affected by healthy and pathological aging.
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DOI：
10.3233/jad-150523
发表时间：
2016
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Wang N;Allali G;Kesavadas C;Noone ML;Pradeep VG;Blumen HM;Verghese J
通讯作者：
Verghese J
影响因子：
3.7
作者：
Salat, DH;Buckner, RL;Fischl, B
通讯作者：
Fischl, B
影响因子：
3.7
作者：
Peters, A;Morrison, JH;Hyman, BT
通讯作者：
Hyman, BT
DOI：
10.1093/gerona/gls191
发表时间：
2013-04-01
影响因子：
5.1
作者：
Verghese, Joe;Wang, Cuiling;Holtzer, Roee
通讯作者：
Holtzer, Roee
影响因子：
14.5
作者：
Habes, Mohamad;Erus, Guray;Davatzikos, Christos
通讯作者：
Davatzikos, Christos